马明 博士 研究员
Ming Ma, Ph. D., Associate Professor (PI)
教育背景
2003.9--2006.7,博士,药物化学,中国医学科学院北京协和医学院药物研究所
2000.9--2003.7,硕士,药物化学,山东中医药大学中药学院
1996.9--2000.7,学士,中药学,山东中医药大学
工作经历
2016.1--现在,入选北京大学“优秀青年人才计划”(研究员),博士生导师,北京大学药学院天然药物学系
2011.5--2016.1,研究助理(Research Associate),美国斯克里普斯(Scripps Florida)研究所化学系
2006.7--2011.4,助理研究员,中国科学院生物物理研究所生物大分子国家重点实验室
Education
2003--2006, Ph. D., pharmaceutical chemistry, institute of materia medica, Chinese academy of medical sciences & Peking union medical college.
2000--2003, M. S., pharmaceutical chemistry, academy of traditional Chinese medicine, Shandong university of traditional Chinese medicine.
1996--2000, B. S., traditional Chinese medicine, academy of traditional Chinese medicine, Shandong university of traditional Chinese medicine.
Research Experiences
2016.1-- current, assistant professor (Tenure-Track, PI), department of natural medicines, school of pharmaceutical sciences, Peking university.
2011.5--2016.1, research associate, department of chemistry, The Scripps Research Institute (Florida).
2006.7--2011.4, assistant professor, institute of biophysics, Chinese academy of sciences.
发表论文(博士和博士后期间)
28. Thomas Kwong#, Ming Ma#, Guohui Pan, Hindra, Dong Yang, Chunying Yang, Jeremy R. Lohman, Jeffrey D. Rudolf, John L. Cleveland, Ben Shen*. P450-catalyzed tailoring steps in leinamycin biosynthesis featuring region- and stereoselective hydroxylations and substrate promiscuities. Biochemistry, 2018, 57, 5005-5013.
27. Thibault Annaval, Lu Han, Jeffrey D Rudolf, Guangbo Xie, Dong Yang, Chin-Yuan Chang, Ming Ma, Ivana Crnovcic, Mitchell D Miller, Jayashree Soman, Weijun Xu, George N Phillips Jr, Ben Shen. Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway. ACS Chem. Biol., 2018, 13, 2728-2738.
26. Chin-Yuan Chang, Jeremy R. Lohman, Tingting Huang, Karolina Michalska, Lance Bigelow, Jeffrey D. Rudolf, Robert Jedrzejczak, Xiaohui Yan, Ming Ma, Gyorgy Babnigg, Andrzej Joachimiak, George N. Phillips, Jr., Ben Shen. Structural insights into the free-standing condensation enzyme SgcC5 catalyzing ester-bond formation in the biosynthesis of the enediyne antitumor antibiotic C-1027. Biochemistry, 2018, 57, 3278-3288.
25. Guohui Pan, Zhengren Xu, Zhikai Guo, Hindra, Ming Ma, Dong Yang, Hao Zhou, Yannick Gansemans, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Jinhua Cheng, Filip Van Nieuwerburgh, Joo-Won Suh, Yanwen Duan, Ben Shen. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proc. Natl. Acad. Sci. U. S . A., 2017, 114, E11131-E11140.
24. Jeffrey D. Rudolf, Chin-Yuan Chang, Ming Ma, Ben Shen. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Nat. Prod. Rep., 2017, 34, 1141-1172.
23. Bo Zhang, Zhengren Xu, Qihui Teng, Guohui Pan, Ming Ma, Ben Shen*. A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angew. Chem. Int. Ed., 2017, 56, 7247-7251.
22. Ming Ma, Mostafa E. Rateb, Dong Yang, Jeffrey D. Rudolf, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Ben Shen*. Germicidins H-J from Streptomyces sp. CB00361. J. Antibiot., 2017, 70, 200-203.
21. Jeffery D. Rudolf, Liao-Bin Dong, Hongnan Cao, Catherine Hatzos-Skintges, Jerzy Osipiuk, Michael Endres, Chin-Yuan Chang, Ming Ma, Gyorgy Babnigg, Andrzej Joachimiak, George N. Phillips, Jr., Ben Shen*. Structure of the ent-copalyl diphosphate synthase PtmT2 from Streptomyces platensis CB00739, a bacterial type II diterpene synthase. J. Am. Chem. Soc., 2016, 138, 10905-10915.
20. Chin-Yuan Chang, Jeremy R. Lohman, Hongnan Cao, Kemin Tan, Jeffrey D. Rudolf, Ming Ma, Weijun Xu, Craig A. Bingman, Ragothaman M. Yennamalli, Lance Bigelow, Gyorgy Babnigg, Xiaohui Yan, Andrzej Joachimiak, George N. Phillips Jr., Ben Shen*. Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate during the biosynthesis of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus. Biochemistry, 2016, 55, 5142-5154..
19. Tingting Huang, Chin-Yuan Chang, Jeremy R Lohman, Jeffrey D Rudolf, Youngchang Kim, Changsoo Chang, Dong Yang, Ming Ma, Xiaohui Yan, Ivana Crnovcic, Lance Bigelow, Shonda Clancy, Craig A Bingman, Ragothaman M Yennamalli, Gyorgy Babnigg, Andrzej Joachimiak, George N Phillips, Ben Shen*. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. J. Antibiot., 2016, 69, 731-740.
18. Ming Ma#, Jeremy R. Lohman#, Tao Liu#, Ben Shen*. C-S bond cleavage by a polyketide synthase domain. Proc. Natl. Acad. Sci. U. S . A., 2015, 112, 10359-10364.
17. Sheng-Xiong Huang#, Bong-Sik Yun#, Ming Ma#, Hirak S. Basu, Dawn R. Church, Gudrun Ingenhorst, Yong Huang, Dong Yang, Jeremy R. Lohman, Gong-Li Tang, Jianhua Ju, Tao Liu, George Wilding, Ben Shen*. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc. Natl. Acad. Sci. U. S. A., 2015, 112, 8278-8283.
16. Ming Ma, Mostafa E. Rateb, Qihui Teng, Dong Yang, Jeffrey D. Rudolf, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Xiuling Li, Christoph Rader, Yanwen Duan, Ben Shen*. Angucyclines and angucyclinones from Streptomyces sp. CB01913 featuring C-ring cleavage and expansion. J. Nat. Prod., 2015, 78, 2471-2480.
15. Jeremy R. Lohman, Ming Ma, Jerzy Osipiuk, Boguslaw Nocek, Youngchang Kim, Chang Changsoo, Marianne Cuff, Jamey Mack, Lance Bigelow, Hui Li, Mike Endres, Gyorgy Babnigg, Andrzej Joachimiak, George N. Phillips, Jr., Ben Shen*. Structural and evolutionary relationships of “AT-less” polyketide synthase ketosynthases. Proc. Natl. Acad. Sci. U. S. A., 2015, 112, 12693-12698.
14. Xiangwei Gao, Ji Wan, Botao Liu, Ming Ma, Ben Shen, Shu-Bing Qian*. Quantitative profiling of initiating ribosomes in vivo. Nat. Methods, 2015, 12, 147-153.
13. Tao Liu, Ming Ma, Hui-Ming Ge, Chunying Yang, John Cleveland, Ben Shen*. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. Bioorg. Med. Chem. Lett., 2015, 25, 4899-4902.
12. Jeffrey D. Rudolf, Lance Bigelow, Changsoo Chang, Marianne E. Cuff, Jeremy R. Lohman, Chin-Yuan Chang, Ming Ma, Dong Yang, Shonda Clancy, Gyorgy Babnigg, Andrzej Joachimiak, George N. Phillips, Jr., Ben Shen*. Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC 21892. Biochemistry, 2015, 54, 6842-6851.
11. Zhilong Yang, Shuai Cao, Craig A. Martens, Zhi Xie, Ming Ma, Ben Shen, Bernard Moss*. Deciphering poxvirus gene expression by RNA sequencing and ribosome profiling. J. Virol., 2015, 89, 6874-6886.
10. Jeong-Woo Seo#, Ming Ma#, Thomas Kong#, Jianhua Ju, Si-Kyu Lim, Hui Jiang, Jeremy R. Lohman, Emmanuel Zazopoulos, Chris M. Farnet, Ben Shen*. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry, 2014, 53, 7854-7865.
9. Pengfei Xie#, Ming Ma#, Mostafa Rateb, Khaled Shaaban, Zhiguo Yu, Shengxiong Huang, Jeremy Lohman, Dong Yang, Jeffrey Rudolf, Ben Shen*. Biosynthetic potential-based strain prioritization for natural product discovery – a showcase for diterpenoid producing actinomycetes. J. Nat. Prod., 2014, 77, 377-387.
8. Jeremy R. Lohman, Ming Ma, Marianne Cuff, Lance Bigelow, Jessica Bearden, Gyorgy Babnigg, Andrzej Joachimiak, George Phillips, Ben Shen*. The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. Proteins, 2014, 82, 1210-1218.
7. Min Yin, Yijun Yan, Jeremy R. Lohman, Sheng-xiong Huang, Ming Ma, Guang-rong Zhao, Li-hua Xu, Wensheng Xiang, Ben Shen*. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Org. Lett., 2014, 16, 3072-3075.
6. Alexander Koch, Daria Gawron, Sandra Steyaert, Elvis Ndah, Jeroen Crappe, Sarah De Keulenaer, Ellen De Meester, Ming Ma, Ben Shen, Kris Gevaert, Wim Van Criekinge, Petra Van Damme, Gerben Menschaert*. A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites. Proteomics, 2014, 14, 2688-2698.
5. Ming Ma#, Thomas Kwong#, Si-kyu Lim, Jianhua Ju, Jeremy R. Lohman, Ben Shen*. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. J. Am. Chem. Soc., 2013, 135, 2489-2492.
4. Noam Stern-Ginossar, Ben Weisburd, Annette Michalski, Vu Thuy Khanh Le, Marco Y. Hein, Sheng-Xiong Huang, Ming Ma, Ben Shen, Shu-Bing Qian, Hartmut Hengel, Matthias Mann, Nicholas T. Ingolia, Jonathan S. Weissman*. Decoding human cytomegalovirus. Science, 2012, 338, 1088-1093.
3. Ming Ma#, Stephen G. Bell#, Wen Yang, Yiming Hao, Nicholas H. Rees, Mark Bartlam, Weihong Zhou, Luet-Lok Wong and Zihe Rao. Structural analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444. ChemBioChem, 2011, 12, 88-99.
2. Ming Ma, Jielu Zhao, Sujuan Wang, Shuai Li, Yongchun Yang, Jiangong Shi*, Fan Xiao and Lan He. Bromophenols coupled with nucleoside bases and brominated tetrahydroisoquinolines from the red alga Rhodomela confervoides. J. Nat. Prod., 2007, 70, 337-341.
1. Ming Ma, Jielu Zhao, Sujuan Wang, Shuai Li, Yongchun Yang, Jiangong Shi*, and Lan He. Bromophenols coupled with methyl gamma-ureidobutyrate and bromophenol sulfates from the red alga Rhodomela confervoides. J. Nat. Prod., 2006, 69, 206-210.