刘涛课题组介绍 更多>>

刘涛 特聘研究员

研究领域:大分子药物,化学生物学

邮箱:taoliu@bjmu.edu.cn

电话:010-82805519

 

刘涛 特聘研究员

Dr. Tao Liu, Principal Investigator, Assistant Professor

国家“千人计划”青年人才(重点支持 300万)

Awardee of "The Recruitment Program of Global Youth Experts"

 

个人简历

2016-至今        北京大学医学部药学院特聘研究员,博士生导师

                        Assistant Professor, School of Pharmaceutical Sciences, Peking University

                        天然药物及仿生药物国家重点实验室PI

                        Principal Investigator, State Key Laboratory of Natural and Biomimetic Drugs

2012-2016       美国California Institute for Biomedical Research科学家,转化医学                                                      

2011-2015       美国The Scripps Research Institute,博士后,化学生物学,导师:Prof. Peter G. Schultz

2005-2011       美国The Ohio State University,理学博士,生物化学专业,导师: Prof. Dehua Pei

2001-2005       南开大学,理学学士,生命科学专业

 

 

 

主要研究领域

1. 以抗体为主的新一代化学修饰类蛋白大分子药物的研发及应用

2. 以蛋白工程为主的化学生物学新技术的研发及应用

3. 以基因密码子扩展技术为主的合成生物学新技术的研发及应用

 

学术奖励及科研成果

 

2016                      中组部第十二批国家“千人计划”青年人才

2010–至今           Associate Faculty Member, Faculty of 1000

2015                      Scripps NewsDrug Discovery News两家科研媒体以及24/7 News电台分别针对长效抗体激素融合药物的 研发对我个人进行了采访报道,并有超过17家世界知名媒体对专访的内容进行了转载报道                                      

 

 

代表性论文及专利

 

Publications

1.     Tao Liu, Yan Wang, Xiaozhou Luo, Jack Li, Sean A. Reed, Han Xiao, Travis S. Young, and Peter G. Schultz*. “Enhancing Protein Stability with Extended Disulfide Bonds” Proc Natl Acad Sci USA 2016, May 24; 113(21):5910-5.

2.     Xiaozhou Luo, Claudio Zambaldo, Tao Liu, Yuhan Zhang, Weimin Xuan, Chen Wang, Sean A. Reed, Peng-YuYang, Rongsheng E. Wang, Tsotne Javahishvili, and Peter G. Schultz* and Travis S. Young*."Recombinant Thiopeptides Containing Noncanonical Amino Acids". Proc Natl Acad Sci USA 2016, Mar 29;113(13):3615-20.

3.     Xiaozhou Luo#, Tao Liu# (共同一作), Ying Wang, Haiqun Jia, Yuhan Zhang, Dawna Caballero, Juanjuan Du, Rongsheng E. Wang, Danling Wang, Peter G. Schultz* and Feng Wang*. "An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold" Angewandte Chemie 2015, 54(48):14531-4.

4.     Tao Liu#, Juanjuan Du#, Xiaozhou Luo, Peter G. Schultz and Feng Wang*. “Homogeneously modified immunoglobulin domains for therapeutic applications”. Curr Opin Chem Biol 2015, 28, 66-74. (IF: 7.7)

5.     Han Xiao, Weimin Xuan, Sida Shao, Tao Liu, Peter G. Schultz*. “Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones” ACS chem biol 2015, 10 (7), 1599–1603. (IF: 5.4)

6.     Tao Liu, Guangsen Fu, Xiaozhou Luo, Yan Liu, Ying Wang, Rongsheng E. Wang, Peter G. Schultz* and Feng Wang*. "Rational Design of Antibody Protease Inhibitors" J Am Chem Soc 2015, 137, 4042. (IF: 11.4)

(This work is recommend by Faculty of 1000 as “Exceptional” )

7.     Rongsheng E. Wang#, Tao Liu# (共同一作), Ying Wang, Yu Cao, Xiaozhou Luo, Vishal Deshmukh, Chan Hyuk Kim, Brian Lawson, Stephanie Pinkerston*, Feng Wang*, Peter G Schultz*. "An Immunosuppressive Antibody-Drug Conjugate" J Am Chem Soc 2015, 137, 3229 (IF: 11.4)

8.     Tao Liu#, Yong Zhang#, Yan Liu#, Ying Wang, Haiqun Jia, Mingchao Kang, Xiaozhou Luo, Dawna Caballero, Jose Gonzalez, Danling Wang, Ashley Woods, Peter G. Schultz* and Feng Wang*. "Functional Human Antibody CDR Fusions as Long-Acting Therapeutic Endocrine Agonists" Proc Natl Acad Sci USA 2015, 112, 1356-61. (IF: 9.8)

(This work is highlighted by Nature Reviews Drug Discovery 14, 166 (2015)

This work is reported worldwide by major scientific media including ScienceDaily news, Drug Discovery News, GEN News, Scripps news, and radio station 24/7 News)

9.     Tao Liu, Yan Liu, Ying Wang, Mitchell Hull, Peter G. Schultz* and Feng Wang*. "Rational Design of CXCR4 Specific Antibodies with Elongated CDRs" J Am Chem Soc 2014, 136, 10557. (IF: 11.4)

10.  Ziqing Qian, Patrick G. Dougherty, Tao Liu, Shameema Oottikkal, Patrick G. Hogan, Christopher M. Hadad, and Dehua Pei*." Structure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction" J Med Chem 2014, 57, 7792. (IF: 5.5)

11.  Ziqing Qian, Tao Liu, Yu-Yu Liu, Roger Briesewitz, Amy Barrios, Sissy Jhiang, and Dehua, Pei*. "Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs" ACS Chem Biol 2013, 8, 423. (IF: 5.4)

12.  Varun Dewan#, Tao Liu# (共同一作), Kuan-Ming Chen , Ziqing Qian, Yong Xiao, Lawrence Kleiman, Kiran V. Mahasenan, Chenglong Li, Hiroshi Matsuo , Dehua Pei* , and Karin Musier-Forsyth*. "Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction" ACS Chem Biol 2012, 7, 761.

13.  Tao Liu, Ziqing Qian, Qing Xiao and Dehua Pei*. “High-Throughput Screening of One-Bead-One-Compound Libraries: Identification of Cyclic Peptidyl Inhibitors against Calcineurin/NFAT Interaction” ACS Comb Sci 2011, 13, 537.

14.  Tao Liu, Yu Liu, Hung-Ying Kao and Dehua Pei*. “Membrane permeable cyclic peptidyl inhibitors against human peptidylprolyl isomerase Pin1.” J Med Chem 2010, 53, 2494.

15.  Tao Liu, Sang Hoon Joo, Jeffrey L. Voorhees, Charles L. Brooks and Dehua Pei*. “Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor” Bioorg Med Chem 2009, 17, 1026.

16.  Tao Liu, Long chen, Sen Hou, Yonglai Xue and Xizeng Feng*. “Non-viral gene delivery carrier of probe type host molecule --Interactions between DNA and β-cyclodextrin derivative complexes (I)” Chinese Science Bulletin 2006, 51, 530.

 

Patent

1.    

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贾盼盼 2013级六年制

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Panpan Jia2013-Present, B.S., School of Pharmaceutical Sciences, Peking University..

凌鑫宇 2013级六年制

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Xinyu Ling2013-present, B.S. (Expected in 2017), School of Pharmaceutical Sciences, Peking UniversityE-mail:xinyu.ling@bjmu.edu.cnTel:15901515612..

黄雨佳 2013级六年制

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Yujia Huang2013-present, B.S. (Expected in 2017), School of Pharmaceutical Sciences, Peking UniversityEmail: yujiahuang@bjmu.edu.cn..

马怀雷 博士后

马怀雷 博士后

Huailei Ma, Ph.D.2016-present, Postdoctoral Fellow, Peking University2012-2016, Ph.D., National Center for Nanoscience and Technology, Chinese Academy of Scien..

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