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导师介绍

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汤新景 博士

 基金委优秀青年基金获得者

 北京大学药学院

 天然药物及仿生药物国家重点实验室

Email: xinjingt@bjmu.edu.cn

 

 教育及研究经历：

 

1993.9 — 1997.7  山东大学化学系，理学学士学位

1997.9 — 2002.7  中国科学院理化技术研究所有机化学专业，理学博士学位   导师：佟振合院士，吴骊珠研究员

2003.9 — 2009.8 美国宾夕法尼亚大学化学系，博士后及研究助理 导师：Ivan J. Dmochowski 教授

2009.9 — 目前   北京大学药学院，天然药物与仿生药物国家重点实验室，课题组长。

 

主要研究领域：

  1. 核苷和寡聚核苷酸的结构修饰及功能调控
  2. 寡聚核苷酸荧光探针的合成及应用
  3. 新型纳米探针的合成，标记及其在肿瘤检测中的应用
  4. 新型小分子荧光探针的合成及其对生物活性小分子的检测和成像

 

在研课题

  1. 中韩国际交流项目，21511140281，光敏感核苷三磷酸类似物用于DNA单分子成像的多色定点标记及其在DNA损伤研究中的应用，2015/07-2017/06
  2. 国家自然科学基金优秀青年基金，21422201，核酸化学生物学，2015/01-2017/12
  3. 国家自然科学基金面上项目, 21372018, 光敏感聚合物载体的设计、合成及其对脂溶性药物的包载和光控制的药物释放, 2014/01-2017/12
  4. 科技部“973”计划，2013CB933800，重大疾病相关的若干重要难检活性小分子细胞内纳米传感研究-子课题1：新型高灵敏度高选择性识别活性小分子的功能纳米荧光探针设计与制备, 2013/1-2017/12
  5. 科技部“973”计划，2012CB720600，基于核酸重大疾病诊断新策略和新技术研究-子课题4:对乳腺癌、肝癌识别的适配子的设计与筛选，2012/01-2016/08

 

代表性论文

 

  1. Xiaoxuan Su, Wenxiao Ma, Boyang Cheng, Qian Wang, Zefeng Guo, Demin Zhou, Xinjing Tang* Efficient Inhibition of SARS-CoV-2 Using Chimeric Antisense Oligonucleotides through RNase L Activation, Angew Chem Int Ed. 2021, doi: 10.1002/anie.202105942 
  2. Changmai Chen, Nannan Jing, Zhongyu Wang, Yu Zhang, Wei Chen, Xinjing Tang* Multimerized self-assembled caged two-in-one siRNA nanoparticles for photomodulation of RNAi induced gene silencing. Chem Sci., 2020, 11, 12289-12297
  3. Yu Zhang§, Xinyu Ling§, Xiaoxuan Su, Shilin Zhang, Jing Wang, Pingjing Zhang, Wenjian Feng, York Yuanyuan Zhu, Tao Liu, Xinjing Tang* Optical Control of CRISPR-Cas9 system for gene editing using photolabile crRNA. Angew Chem Int. Ed. 2020, 132, 21081-21085
  4. Jing Wang, Duanwei Liang, Jie Feng, Xinjing Tang* Multi-color Cocktail for Breast Cancer Multiplex Phenotype Targeting and Diagnosis Using Bioorthogonal Surface-Enhanced Raman Scattering Nanoprobes, Anal. Chem., 2019, 91(17), 11045-11054
  5. QingQing Jin, Xinli Fan, Changmai Chen, Lei Huang, Jing Wang, Xinjing Tang*, Multicolor Raman Beads for Multiplexed Tumor Cell and Tissue Imaging and in Vivo Tumor Spectral Detection, Anal Chem., 2019, 91, 3784−3789
  6. Liangliang Zhang, Duanwei Liang, Yuan Wang, Dong Li, Jinhao Zhang, Li Wu, Mengke Feng, Fan Yi, Luzheng Xu, Liandi Lei, Quan Du and XinJing Tang* Caged circular siRNAs for photomodulation of gene expression in cells and mice Chem. Sci., 2018, 9, 44 – 51
  7. Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu, Xinjing Tang* Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification, Angew Chem Intl Ed. 2016,55, 2152-2156
  8. Pengfei Li, Hongyan He, Zhixuan Wang, Mengke Feng, Hongwei Jin, Yun Wu, Liangren Zhang and Lihe Zhang, Xinjing Tang, Sensitive detection of single nucleotide mutation in BRAF mutation site (V600E) of human melanoma using phosphate-pyrene-labelled DNA probesAnal. Chem., 2016, 88, 883-889
  9. Zhisheng Wu, Xinjing Tang*, Visualizing Fluoride ion in Mitochondria and Lysosome of Living Cells and in Living Mice with Positively Charged Ratiometric Probes Anal. Chem., 2015, 87, 8613-8617.
  10. Junzhou Wu, Duanwei Liang, Qingqing Jin, Jie Liu, Meiling Zheng Xuanming Duan, and Xinjing Tang*, Bioorthogonal SERS Nanoprobes for Mulitplex Spectroscopic Detection and Tumor Cell Targeting and Tissue Imaging, Chem. Eur. J., 2015, 21,12914-12918.
  11. Long Li, Yuzhuo, Xinjing Tang*, Quaternary Ammonium Promoted Ultra Selective and Sensitive Fluorescence Detection of Fluoride Ion in Water and Living Cells, Anal. Chem., 2014, 86, 10006-10009
  12. Xiuxian Chen, Qingqing Jin, Lizhu Wu, ChenHo Tung,Xinjing Tang*, Synthesis and Unique Photoluminescence Properties of Novel Nitrogen-rich Quantum dots and Their Applications, Angew Chem. Int. Ed., 2014, 53, 12542-12547
  13. Li Wu, Fen Pei, Jinhao Zhang, Junzhou Wu, Mengke Feng, Yuan Wang, Hongwei Jin, Liangren Zhang, Xinjing Tang* Synthesis of Site-specifically Phosphate-caged siRNAs and Evaluation of their RNAi Activity and Stability, Chem. Eur. J., 2014, 20, 12114-12122
  14. Li Wu, Yuan Wang, Junzhou Wu, Jie Wang, Xinjing Tang* Caged Circular Antisense Oligonucleotides for Photomodulation of RNA Digestion and Gene Expression in Cells. Nucleic Acids Res., 2013, 41. 677-686
  15. Yuan Wang, Li Wu, Peng Wang, Cong Lv, Zhenjun Yang and Xinjing Tang* Manipulation of gene expression in zebrafish using caged circular morpholino oligomersNucleic Acids Res., 2012, 40, 11155-11162.
  16. Meng Su, Jie Wang, and XinJing Tang*，Photocaging Strategy for Functionalisation of Oligonucleotides and Its Applications for Oligonucleotide Labelling and CyclisationChem. Eur. J. 2012, 18, 9628-9637
  17. XinJing Tang*, Meng Su, LiLi Yu, Cong Lv, Jie Wang, and ZhongJin Li， Photomodulating RNA cleavage using photolabile antisense oligodeoxynucleotides Nucleic Acids Res., 2010, 38, 3848
  18. XinJing Tang, Jyothishmathi Swaminathan, Alan M. Gewirtz, Ivan J. Dmochowski, “Regulating Gene Expression in Human Leukemia Cells Using Light-Activated Oligodeoxynucleotides”, Nucleic Acids Res.,2008, 36, 559-569.
  19. XinJing Tang, Shingo Maegawa, Eric S. Weinberg, Ivan J. Dmochowski, “Regulating Gene Expression in Zebrafish Embryos Using Light-Activated, Negatively Charged Peptide Nucleic Acids”, J. Am. Chem. Soc.,2007, 129 (36), 11000-11001
  20. XinJing Tang, Ivan J. Dmochowski, “Controlling RNA digestion by RNase H with a light-activated DNA hairpin”,Angew. Chem. Int. Ed., 2006, 45, 3523-3526.