email: niuyouhong@bjmu.edu.cn
Tel: 010-82805732
教育背景与工作经历
2013/12-至今,天然药物及仿生药物国家重点实验室和药物化学系 , 助理研究员、副研究员
2010/04-2013/07,南佛罗里达大学化学系，药物化学，博士后
2008/09-2010/03,保诺(北京)科技有限公司，项目组长
2004/09-2008/07,兰州大学，有机化学，博士学位，导师：曹小平、叶新山 教授
2001/09-2004/07,兰州大学，有机化学，硕士学位，导师：叶新山、曹小平 教授
1997/09-2001/07,武汉工程大学，药物制剂，工学学士
研究领域
基于糖和肽模拟物的药物研究:
1) 新型抗菌药物研究——抗菌肽模拟物、模拟物与现有抗菌药物的杂合体
2) 糖尿病药物——PTP1B和糖原磷酸化酶抑制剂
3) 抗肿瘤药发现————STATs
4) 膜通透性的糖基转移酶探针研究
科研项目
3) 2020/01-2023/12, 结构多样氮杂糖的合成及其免疫抑制和作用机制研究，国家自然基金面上项目，项目负责人，在研(21977004)
2) 2016/01-2017/12, 抗菌肽小分子模拟物的设计、合成及抗菌相关性质的研究,国家自然基金面上项目，项目负责人，已结题。
1) 2016/11-2016/12,药学院青年培育基金.
荣誉与奖励
2016年度北京大学医学部教学优秀奖
研究成果
[42] Li-Na Wang #, You-Hong Niu # , Qing-Hui Cai, Qin Li*, Xin-Shan Y. Tetrahedron 2021, 82, 131955.
[41] 李 涛，牛有红∗ ，叶新山∗ . Recent advances on non-peptide or small molecule mimics of antimicrobial peptide. Chinese Journal of Medicinal Chemistry, 2020, 30(30),159.
[40] Youhong Niu,* Minghui Wang, Yafei Cao, Alekhya Nimmagadda, Jianxing Hu, Yanfen Wu, Jianfeng Cai,* Xin-Shan Ye.* Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents. J. Med. Chem. 2018, 61, 2865−2874.
[39] Zhuo Lv, Chengcheng Song, Youhong Niu, Qin Li,* Xin-Shan Ye.* Synthesis of N-Substituted Iminosugar Derivatives and Evaluation of Their Immunosuppressive Activities. ChemMedChem 2018, 13, 338 – 351.
[38] Shuo Zhang#, You-Hong Niu#, and Xin-Shan Ye. General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C−H Functionalization Strategy. Org. Lett. 2017, 19, 3608−3611.
[37] Hai-Qian Liu, Cheng-Cheng Song, You-Hong Niu, Tao Li,a Qin Li, Xin-Shan Ye. Synthesis and biological evaluation of N-arylated-lactam-type iminosugars as potential immunosuppressive agents. Org. Biomol. Chem. 2017, 15, 5912–5919.
[36] Minglong Liu#, Youhong Niu#, Yan-Fen Wu, and Xin-Shan Ye. Ligand-Controlled Monoselective C-Aryl Glycoside Synthesis via Palladium-Catalyzed C−H Functionalization of N-Quinolyl Benzamides with 1‑Iodoglycals. Org. Lett. 2016,18, 1836.
[35] Nana Zeng#, Youhong Niu#, Xin-Shan Ye. 3-Butenyloxycarbonyl as a new hydroxyl protecting group in carbohydrate synthesis. Tetrahedron Lett. 2016, 57, 2935–2938.
[34] Haifeng Wang#, Youhong Niu#, Guoying Zhang, Xin-Shan Ye. A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O-functionalization of sp3 C-H bonds. Tetrahedron Lett. 2016, 57, 4544
[33] Xiaohui Bai, Youhong Niu#, Jingjing Zhu, An-Qi Yang, Yan-Fen Wu, Xin-Shan Ye. A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus. Bioorg. Med. Chem. 2016, 24, 1163.
[32] Wenming Li, Youhong Niu, De-Cai Xiong, Xiaoping Cao, Xin-Shan Ye. Highly Substituted Cyclopentane−CMP Conjugates as Potent Sialyltransferase Inhibitors. J. Med. Chem. 2015, 58, 7972.
[31] Hui-Xin Luo, Youhong Niu, Xiao-Ping Cao, Xin-Shan Ye. Cyclopropenes for the Synthesis of Cyclopropane-Fused Dihydroquinolines and Benzazepines. Adv. Synth. Catal. 2015, 357, 2893.
[30] Hui-Xin Luo, Youhong Niu, Xiaojie Jin, Xiao-Ping Cao, Xiaojun Yao, Xin-Shan Ye. Indolo-quinoline boron difluoride dyes: synthesis and spectroscopic properties. Org. Biomol. Chem. 2016, 14, 4185.
[29] Shao-Tao Bai, Decai Xiong, Youhong Niu,Yan-Fen Wu, Xin-Shan Ye. “Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2 inhibition activities.Tetrahedron 2015, 71, 4909.
[28] WenYang Gao, Yao Chen, Youhong Niu, Kia Williams, Lindsay Cash, Pastor Perez, Lukasz Wojtas ,Jianfeng Cai , Yu-Sheng Chen and Shengqian Ma*. Crystal engineering of an nbo topology MOF for chemical fixation of CO2 under ambient conditions. Angew Chem. Int. Ed., 2014, 53, 2615-2619.
[27] Haifan Wu, Yaqiong Li, Ge Bai, Youhong Niu, Qiao Qiao, Jeremiah Tipton, Chuanhai Cao,* Jianfeng Cai.* γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation. Chem. Commun. 2014, 50, 5206 - 5208.
[26] Haifan Wu, Peng Teng, Youhong Niu, Qi Li, Jianfeng Cai.* Polymyxin derivatives: a patent evaluation (WO2012168820). Expert Opin. Ther. Pat., 2013, 23, 1075-1081.
[25] Yaqiong Li, Haifan Wu, Youhong Niu, Yaogang Hu, Qi Li, Chuanhai Cao, Jianfeng Cai.* Development of RNA Aptamer-Based Therapeutic Agents. Curr. Med. Chem. 2013, 20, 3655-3663.
[24] Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao and Jianfeng Cai.* AApeptides as a new class of antimicrobial agents. Org. Biomol. Chem. 2013, 11, 4283-4290.
[23] Youhong Niu, Haifan Wu, Rongfu Huang, QiaoQiao, Frankie Costanza, Xi-Sen Wang, Yaogang Hu, Mohamad Nassir Amin, Anh-My Nguyen, James Zhang, Edward Haller, Shengqian Ma, Xiao Li, and JianfengCai*. Nanorods formed from a new class of peptidomimetics. Macromolecules, 2012, 45, 7350.
[22] Youhong Niu, Rongsheng E. Wang, Haifan Wu, Jianfeng Cai*. Recent development of small antimicrobial peptidomimetics. Future Med. Chem. 2012, 4(14), 1853.
[21] Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, QiaoQiao, Yaogang Hu, Lacey Harrington, Whittney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Lipo-γ-AApeptides as a new class of potent and broad-spectrum antimicrobial agents. J. Med. Chem.2012, 55(8), 4003.
[20] Youhong Niu, Ge Bai, Haifan Wu, Rongsheng E. Wang, QiaoQiao, Shruti Padhee, Robert Buzzeo, Chuanhai Cao*, and Jianfeng Cai*. Cellular translocation of a γ-AApeptide mimetic of Tat peptide. Mol. Pharmaceutics.2012, 9, 1529.
[19] Yunan Yang#, Youhong Niu#, Hao Hong, Haifan Wu, Yin Zhang, Jonathan W. Engle, Todd E. Barnhart, Jianfeng Cai*, and Weibo Cai*. Radiolabeled γ-AApeptides: A New Class of Tracers for Positron Emission Tomography. Chem. Commun.2012, 48, 7850.
[18] Haifan Wu, Mohamad Nassir Amin, Youhong Niu, QiaoQiao, Nassier Harfouch, AbdelfattahNimer, Jianfeng Cai*. Solid Phase Synthesis of γ-AApeptides Using a Novel Submonomeric Approach. Org. Lett. 2012, 14, 3446.
[17] Haifan Wu, Youhong Niu, Shruti Padhee, Rongsheng E Wang, Yaqiong Li, QiaoQiao, Ge Bai, Chuanhai Cao, and Jianfeng Cai*. Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development. Chem. Sci.2012, 3, 2570.
[16] Wen-Yang Gao , Youhong Niu , Yao Chen , Lukasz Wojtas , Jianfeng cai , Yu-Sheng Chen and Shengqian Ma*. Porous Metal-Organic Framework Based on a MacrocyclicTetracarboxylate Ligand Exhibiting Selective CO2 Uptake. CrystEngComm.,2012, 14, 6115.
[15] Ge Bai, Shruti Padhee, Youhong Niu, Rongsheng E. Wang, Robert Buzzeo, Chuanhai Cao*, Jianfeng Cai*. Cellular uptake of an α-AApeptide. Org. Biomol. Chem. 2012, 10 (6), 1149.
[14] JingjingZhang ,Youhong Niu, Xiaoping Cao, Xin-Shan Ye*. Convenient one-pot synthesis of thiosugars and their efficient conversion to polyoxygenatedcycloalkenes. Tetrahedron 2012, 68, 4242 .
[13] Rongsheng E. Wang,* Frankie Costanza, Youhong Niu, Haifan Wu, Yaogang Hu, Whitney Hang, Yiqun Sun, Jianfeng Cai.* Development of self-immolativedendrimers for drug delivery and sensing. J. Control. Release.2012, 159, 154.
[12] Rongsheng E. Wang, Youhong Niu, Haifan Wu, Yaogang Hu, Jianfeng Cai*. Development of NGR-Based Anti-Cancer Agents for Targeted Therapeutics and Imaging. Anticancer Agents Med. Chem. 2012, 12 (1), 76.
[11] Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Lacey Harrington, Whitney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. Chem. Commun. 2011, 47 (44), 12197.
[10] Youhong Niu, Alisha “Jonesy” Jones, Haifan Wu, Gabriele Varani,* and Jianfeng Cai.* γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org. Biomol. Chem. 2011, 9 (19), 6604.
[9] Youhong Niu, Yaogang Hu, Xiaolong Li, Jiandong Chen, and Jianfeng Cai*.Gamma-AApeptides: Design, Synthesis and Evaluation New J.Chem.2011, 35, 542.
[8] Rongsheng E. Wang,* Haifan Wu, Youhong Niu, and Jianfeng Cai*.Improving the stability of aptamers by chemical modification. Curr. Med. Chem. 2011, 18, 4126.
[7] Rongsheng E. Wang, Youhong Niu, Haifan Wu, Mohamad Nassir Amin, and Jianfeng Cai*. Development of NGR peptide-based agents for tumor imaging. Am. J. Nucl. Med. Mol. Imaging2011, 1(1), 36.
[6] Shruti Padhee, Yaogang Hu, Youhong Niu, Ge Bai, Haifan Wu, Frankie Costanza, Leigh West, Lacey Harrington, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Non-Hemolytic γ-AApeptides as Antimicrobial Peptidomimetics. Chem. Commun. 2011, 47 (34), 9729.
[5] Youhong Niu, Xiaoping, Cao, Xinshan Ye*. Improved Synthesis of Phytosphingosine and Dihydrosphingosine from 3, 4, 6-Tri-O-benzyl Galacal. Helv. Acta.Chem. 2008, 91, 746.
[4] Youhong Niu, Ning, Wang, Xiaoping, Cao, Xinshan Ye*.Efficient formation and cleavage of BenzylideneAcetals by Sodium Hydrogen Sulfate Supported on Silica Gel. Synlett. 2007, 2116.
[3] Youhong Niu, Xiaoping Cao, Xinshan Ye*. Advances in influenza virus sialidase inhibitors. Progress in Chemistry (In Chinese). 2007, 19, 420.
[2] Youhong Niu, Xiaoping Cao,Lihe Zhang, XinShan Ye*. Design and synthesis of sialidase inhibitors. Chin. J. Org. Chem. 2003, 23, 8.
[1] Xiaofang Wang; Youhong Niu, Xiaoping Cao,Liangren Zhang, Lihe Zhang,Xinshan Ye*. 3D-QSAR analysis of sialytransferase inhibitors. Bioorg. Med. Chem. 2003, 19, 4217.
Patents
3. 牛有红，叶新山、吴艳芬、曹亚飞，一种对二苯甲酰二聚体衍生物及其合成方法和应用。201810070032.7, 01/24/2018
2. Jianfeng Cai*, Youhong Niu, Weibo Cai, and Hao Hong. RGD mimetic γ-AApeptides and methods of use. 2012, Application No. 61/667035.
1. Jianfeng Cai*, Youhong Niu, Haifan Wu, Shruti Padhee. “Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.”2012, Application No. 61589406.
BOOK CHAPTER
1. Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai*. Synthesis of AApeptides. Link. Peptide Modifications to Increase Metabolic Stability and Activity, 2013, ISBN: 978-1-62703-651-1.
2. Youhong Niu, Yaogang Hu, Rongsheng E. Wang, Xiaolong Li, Haifan Wu, Jiandong Chen* and Jianfeng Cai*. AApeptides as a New Class of Peptidomimetics to Regulate Protein-Protein Interactions. Link. Protein Interactions, 2012, ISBN: 978-953-51-0244-1.