郑秀静 博士 助理研究员

email: zhengxj@bjmu.edu.cn

Tel: 010-82805460

教育及工作经历

2006.8-至今，北京大学药学院 天然药物及仿生药物国家重点实验室，助理研究员

2003.9-2006.7, 北京大学药学院药物化学博士研究生，导师：叶新山教授

2001.1-2001.8，北京双鹭药业股份有限公司，临床研究助理

1997.9-2000.7，辽宁省锦州医学院 药理学硕士研究生

研究领域

抗肿瘤糖疫苗的研究以及糖类结构的其他活性研究。

荣誉奖励

叶新山，熊德彩，郑秀静，王媛，吴艳芬，李勤，“基于糖类的药物先导化合物的发现和优化研究”， 2011 年中国药学会科学技术奖，一等奖

研究成果：

论文：

1. X.-J. Zheng（共同一作1/2）, F. Yang, M.-W. zheng, C.-X, Huo, Y. Zhang, X.-S. Ye. Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen. Org. Biomol. Chem. 2015, 13, 6399-6406.

2. S. Sun, X.-J. Zheng（共同一作2/2）, C.-X, Huo, C.C. Song, Q. Li, X.-S. Ye. Synthesis and evaluation of glycoconjugates comprising N-acyl-modified Thomsen-Friedenreich antigens as anticancer vaccines. ChemMedChem. 2016, 11, 1090-1096.

3. A. Xiao, X.-J. Zheng（共同一作2/2）, C.C. Song, Y. Gui, C.-X, Huo, X.-S. Ye. Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines. Org. Biomol. Chem. 2016, 14，7226-37.

4. F. Yang, X.-J. Zheng（共同一作2/2）, C.-X, Huo, Y. Wang, Y. Zhang, X.-S. Ye. Enhancement of the immunogenicity of synthetic carbohydrate vaccines by chemical modifications of STn antigen. ACS Chem. Biol. 2011, 6, 252-259.

5.C.C. Song, X.-J. Zheng, C.-C. Liu, Y. Zhou*, X.-S. Ye*. A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model.

6. C.-X. Huo, X.-J. Zheng, A. Xiao, C.-C. Liu, S.Sun, Z. Lv, X.-S. Ye*. Synthetic and immunological studies of N-Acyl modified S-Linked STn derivatives as anticancer vaccine candidates. Org. Biomol. Chem. 2015, 13, 3677-3690.

7. C.-C. Liu, X.-J. Zheng, X.-S. Ye*. Broadly Neutralizing antibody-guided carbohydrate-based HIV vaccine design: challenges and opportunities. ChemMedChem. 2016, 11, 357 – 362.

8. C.C. Song, S. Sun, C.-X, Huo, Q. Li, X.-J. Zheng, G.H. Tai, Y.F. Zhou*, X.-S. Ye*. Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates. Bioorg. Med. Chem. 2016, 24, 915-920.

9. G.-L. Zhang, X.-J. Zheng, L.-H. Zhang, X.-S. Ye*. Design and syntheses of some iminosugar derivatives as potential immunosuppressants. Med. Chem. Commun. 2011, 2, 909-917.

10. L. Yang, J.J. zhu, X.-J. Zheng, G.H. Tai, X.-S. Ye*. A highly a-stereoselective synthesis of oligosaccharide fragments of the Vi antigen from salmonella typhi and their antigenic activities. Chem. Eur. J. 2011, 17, 14518 – 14526。

专利：叶新山; 郑秀静; 杨帆（2/3）, 唾液酸（α-(2→6)）-D-吡喃糖衍生物及其合成方法和应用, 2011.4.8, 美国, PCT/CN2011/000610