E-mail: jiaqi.sun@bjmu.edu.cn
毕业去向:
博后
教育经历:
2013.9-2017.7 北京大学医学部 药学院 学士
2017.9-2023.7 北京大学医学部 药学院 化学生物学系 博士,导师:周德敏 教授
研究领域:
靶向性和多功能蛋白药物设计
荣誉奖励:
北京大学优秀学习奖,北京大学光华奖学金(2014)
北京大学三好学生,北京大学叔蘋奖学金(2015)
北京大学三好学生标兵,北京大学树人奖学金,北京大学医学部优秀医学生特等奖学金(2016)
北京大学优秀毕业生,北京大学久信直博新生奖学金(2017)
澳门大学首届中华医药博士生创新型创业大赛片仔癀特等奖(2019)
北京大学博士创新人才奖学金(2020)
第一届北大生物医学论坛学生专场,学术创新奖(2020)
北京大学三好学生,北京大学学术创新奖,国家奖学金(2021)
北京大学三好学生,北京大学学术创新奖,张礼和院士-浙江医药奖学金(2022)
上海罗氏大学研究基金一等奖(2022)
北京大学优秀毕业生,北京市优秀毕业生,北京大学优秀博士论文(2023)
研究成果:
1) Ji. D#, Y. Zhang#, J. Sun, B. Zhang, B. Cheng, W. Ma, X. Wang, Y. Li, H. Bao, H. Xu, Q. Wang, C. Zhang, S. Xiao*, L. Zhang* and D. Zhou*. "Chimeric Antigenic Peptide Influenza Virus as a Personalized Therapeutic Cancer Vaccine." (Accepted) Nat. Biotechnol., 2023.
2) B. Zhang#, J. Sun#, Y. Yuan#, D. Ji#, Y. Sun#, Y. Liu, S. Li, X. Zhu, X. Wu, J. Hu, L. Wu, L. Liu, B. Cheng, Y. Zhang, L. Jiang, L. Zhao, F. Yu, W. Song, M. Wang, Y. Fei, L. Zhang*, D. Zhou*, X. Zhang*. "The proximity-enabled covalent binding of IL-2 to CD25 selectively and persistently promotes Tregs activation and suppresses autoimmunity." Signal Transduct. Target. Ther., 2023, 8(1): 28. (These authors contributed equally)
3) B. Zhang#, J. Sun#, Y. Wang#, D. Ji#, Y. Yuan#, S. Li, Y. Sun, Y. Hou, P. Li, L. Zhao, F. Yu, W. Ma, B. Cheng, L. Wu, J. Hu, M. Wang, W. Song, X. Li, H. Li, Y. Fei, H. Chen, L. Zhang, G. C. Tsokos*, D. Zhou* and X. Zhang*. "Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells." Nat. Biomed. Eng., 2021, 5(11): 1288-1305. (These authors contributed equally)
4) B. Zhang#, Y. Wang#, Y. Yuan#, J. Sun, L. Liu, D. Huang, J. Hu, M. Wang, S. Li, W. Song, H. Chen, D. Zhou* and X. Zhang*. "In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells." Ann. Rheum. Dis., 2021, 80(2): 176-184.
5) B. Zhang#, Y. Wang#, S. Huang#, J. Sun, M. Wang, W. Ma, Y. You, L. Wu, J. Hu, W. Song, X. Liu, S. Li, H. Chen, G. Zhang, L. Zhang*, D. Zhou*, L. Li* and X. Zhang*. "Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator." Cell Chem. Biol., 2021, 28(1): 60-69. e67.
6) H. Li, J. Sun, S. Xiao*, L. Zhang* and D. Zhou*. "Triterpenoid-Mediated Inhibition of Virus-Host Interaction: Is Now the Time for Discovering Viral Entry/Release Inhibitors from Nature?" J. Med. Chem., 2020, 63(24): 15371-15388.
7) Y. Wang#, S. Li#, Z. Tian, J. Sun, S. Liang, B. Zhang, L. Bai, Y. Zhang, X. Zhou, S. Xiao*, Q. Zhang*, L. Zhang*, C. Zhang* and D. Zhou*. "Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction." Nucleic Acids Res., 2019, 47(19): e114.
8) Y. Su, L. Meng, J. Sun, W. Li, L. Shao, K. Chen, D. Zhou*, F. Yang* and F. Yu*. "Design, synthesis of oleanolic acid-saccharide conjugates using click chemistry methodology and study of their anti-influenza activity." Eur. J. Med. Chem., 2019, 182: 111622.
9) W. Li, F. Yang, L. Meng, J. Sun, Y. Su, L. Shao, D. Zhou* and F. Yu*. "Synthesis, Structure Activity Relationship and Anti-influenza A Virus Evaluation of Oleanolic Acid-Linear Amino Derivatives." Chem. Pharm. Bull., 2019, 67(11): 1201-1207
10) L. Si, K. Meng, Z. Tian, J. Sun, H. Li, Z. Zhang, V. Soloveva, H. Li, G. Fu*, Q. Xia*, S. Xiao*, L. Zhang* and D. Zhou*. "Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes." Sci. Adv., 2018, 4(11): eaau8408.
11) Y. Shi, L. Si, X. Han, Z. Fan, S. Wang, M. Li, J. Sun, Y. Zhang, D. Zhou* and S. Xiao*. "Synthesis of novel pentacyclic triterpene–Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity." MedChemComm, 2017, 8(7): 1531-1541.
12) 受体偏向的PEG化IL-2的变体组合及其应用。专利号:202210415266.7(学生第一)
13) 靶向调节T细胞的长效白介素-2及其在治疗自身免疫病中的应用。专利号:201911120718.3
14) 可共价交联CD25的白细胞介素-2及其在自身免疫病治疗中的应用。专利号:202111293777.8
15) 突变的流感病毒、药物组合物及用途。专利号:PCT/CN2022/114416
精彩花絮: