Prof. Xin-Shan Ye
Organic Chemistry; Medicinal Chemistry; Chemical Glycobiology
CONTACT INFORMATION
Work Address: School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd No. 38, Beijing 100191, China
Telephone/Fax: +86-10-82805736
E-mail: xinshan@bjmu.edu.cn
• B.Sc. Wuhan University, 1981-1985
• M. Sc. Wuhan University, 1985-1988 (supervised by Prof. Cheng-Tai Wu, Synthesis of crown ether compounds)
• Ph.D. The Chinese University of Hong Kong, 1993-1996 (supervised by Prof. Henry N. C. Wong, Synthesis of 3,4-disubstituted thiophenes)
• Lecturer Huazhong Agricultural University, 1988-1993
• Research Associate The Scripps Research Institute, USA, 1996-2000 (under the direction of Prof. Chi-Huey Wong, Synthesis of oligosaccharide library)
• Professor Peking University, 2000-
• Cheung Kong Scholars Programme Professionship (2000)
• National Outstanding Young Investigator Award by Natural Science Foundation of China (2005)
• Director of the State Key Laboratory of Natural and Biomimetic Drugs (2005-present)
• Natural Science Award of Ministry of Education, China, Second Class (2010)
• WuXi PharmaTech Life Science and Chemistry Award, Second Class (2010)
• Science and Technology Award of Chinese Pharmaceutical Association, First Class (2011)
• Development of new methodologies or strategies for the assembly of oligosaccharides.
• Synthesis and evaluation of biologically important oligosaccharides such as tumor-associated antigens.
• Design, synthesis and evaluation of carbohydrate-processing enzyme inhibitors as well as discovery of new carbohydrate-based drugs.
• Chemical modifications of aminoglycoside antibiotics.
• Co-Editors-in-Chief of Current Topics in Medicinal Chemistry (2014-)
• Member of International Advisory Board of ChemMedChem (2014-)
• Member of Editorial Board of Carbohydrate Research (2009-)
• Member of Editorial Board of Chinese Journal of Organic Chemistry (2007-)
• Member of Editorial Board of Chemical Journal of Chinese Universities (2007-)
• Member of Editorial Board of Chinese Journal of Medicinal Chemistry (2006-)
• Member of Editorial Board of Chinese Journal of New Drugs (2009-)
• Member of Editorial Board of Acta Scientiarum Naturalium Universitatis Pekinensis (2005-)
• Associate Editor-in-Chief of Journal of Chinese Pharmaceutical Sciences (2005-)
1. C.-H. Wong, Z. Zhang, I. Ollmann, T. Baasov and X.-S. Ye, "Programmable One-Pot Oligosaccharide Synthesis and Structural Effects of Monosaccharides on the Anomeric Glycosylation Reactivity", PCT Int. Appl. (2000), 109 pp. CODEN: PIXXD2 WO 0009527 Al 20000224; US patent No.: US 6,538,117 B1.
2. Xin-Shan Ye, Xiao-Lian Zhang, Fang Sun, Li-He Zhang, “Iminosugar derivatives: their synthesis and applications as immunosuppressive agents and glycosidase inhibitors”, Chinese patent No.: ZL 03 1 56099.7, Sept. 1, 2003.
3. Xin-Shan Ye, Yuhang Wang, Li-He Zhang, “Synthesis of the pentasaccharide antigen against hyper-rejection in organ xeno-transplantation”, Chinese patent No.: ZL 2004 1 0050073.8, July 2, 2004.
4. Xin-Shan Ye, Xuefei Huang, Qingyan Yan, Li-He Zhang, “Tri- and penta-saccharide antigens: their synthesis and applications as anti-immunorejection drugs”, Chinese patent No.: ZL 03 1 56098.9, Sept. 1, 2003.
5. Xin-Shan Ye, Jian Zhou, Li-He Zhang, Xiao-Lian Zhang, “A type of N-alkylated 1,6-dideoxyiminosugar derivatives: their synthesis and applications”, Chinese patent No.: ZL 2005 1 0109138.6, Oct. 18, 2005
1. Yao, Wenlong; Xiong, De-Cai; Yang, Yun; Geng, Chunmei; Cong, Zisen; Li, Feifei; Li, Bo-Han; Qin, Xianjin; Wang, Li-Na; Xue, Wan-Ying; Yu, Nengfu; Zhang, Hanyu; Wu, Xia; Liu, Miao; Ye, Xin-Shan. Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer. Nature Synthesis, 2022, 1, 854-863.
2. Wu, Yong; Xiong, De-Cai; Chen, Si-Cong; Wang, Yong-Shi; Ye, Xin-Shan. Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units. Nature Communications, 2017, 8, 14851.
3. Wu, Xiangyang; Wu, Yong; Zheng, Ruijuan; Tang, Fen; Qin, Lianhua; Lai, Detian; Zhang, Lu; Chen, Lingming; Yan, Bo; Yang, Hua; Wang, Yang; Li, Feifei; Zhang, Jinyu; Wang, Fei; Wang, Lin; Cao, Yajuan; Ma, Mingtong; Liu, Zhonghua; Chen, Jianxia; Huang, Xiaochen; Wang, Jie; Jin, Ruiliang; Wang, Peng; Sun, Qin; Sha, Wei; Lyu, Liangdong; Moura-Alves, Pedro; Dorhoi, Anca; Pei, Gang; Zhang, Peng; Chen, Jiayu; Gao, Shaorong; Randow, Felix; Zeng, Gucheng; Chen, Chang; Ye, Xin-Shan; Kaufmann, Stefan H. E.; Liu, Haipeng; Ge, Baoxue. Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. EMBO Reports, 2021, 22, e51678.
4. Huang, Xuefei; Huang, Lijun; Wang, Haisheng; Ye, Xin-Shan. Iterative one-pot synthesis of oligosaccharides. Angewandte Chemie International Edition, 2004, 43, 5221-5224.
5. Liu, Kai-Meng; Wang, Peng-Yu; Guo, Zhen-Yan; Xiong, De-Cai; Qin, Xian-Jin; Liu, Miao; Liu, Meng; Xue, Wan-Ying; Ye, Xinshan. Iterative Synthesis of 2-Deoxyoligosaccharides Enabled by Stereoselective Visible-Light Promoted Glycosylation. Angewandte Chemie International Edition, 2022, 61, e202114726.
6. Liu, Miao; Liu, Kai-Meng; Xiong, De-Cai; Zhang, Hanyu; Li, Tian; Li, Bohan; Qin, Xianjin; Bai, Jinhe; Ye, Xin-Shan. Stereoselective Electro-2-deoxyglycosylation from Glycals. Angewandte Chemie International Edition, 2020, 59, 15204-15208.
7. Sun, Lifeng; Wu, Xiaowei; Xiong, De-Cai; Ye, Xin-Shan. Stereoselective Koenigs-Knorr Glycosylation Catalyzed by Urea. Angewandte Chemie International Edition, 2016, 55, 8041-8044.
8. Liu, Mingli; Qin, Xianjin; Ye, Xin-Shan. Glycan Assembly Strategy: From Concept to Application. Chemical Record, 2021, 21, 3256-3277.
9. Mao, Run-Ze; Xiong, De-Cai; Guo, Fan; Li, Qin; Duan, Jinyou; Ye, Xin-Shan. Light-driven highly efficient glycosylation reactions. Organic Chemistry Frontiers, 2016, 3, 737-743.
10. Qin, Xianjin; Ye, Xin-Shan. Donor Preactivation-Based Glycosylation: An Efficient Strategy for Glycan Synthesis. Chinese Journal of Chemistry, 2021, 39, 531-542.
11. Li, Bo-Han; Ye, Xin-Shan. Recent advances in glycan synthesis. Current Opinion in Chemical Biology, 2020, 58, 20-27.
12. Yang, Fan; Zheng, Xiu-Jing; Huo, Chang-Xin; Wang, Yue; Zhang, Ye; Ye, Xin-Shan. Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen. ACS Chemical Biology, 2011, 6, 252-259.
13. Mo, Juan; Zou, You; Li, Bo-Han; Li, Gefei Zheng, Xiu-Jing; Liu,Yang; Ye, Xin-Shan. Tumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response. ACS Applied Materials & Interfaces, 2023, 15, 40201-40212.
14. Song, Chengcheng; Zheng, Xiu-Jing; Liu, Chang-Cheng; Zhou, Yifa; Ye, Xin-Shan. A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model. Oncotarget, 2017, 8, 47330-47343.
15. Liu, Chang-Cheng; Zhai, Canjia; Zheng, Xiu-Jing; Ye, Xin-Shan. Altering the Specificity of the Antibody Response to HIV gp120 with a Glycoconjugate Antigen. ACS Chemical Biology, 2016, 11, 1702-1709.
16. Liu, Chang-Cheng; Ye, Xin-Shan. Carbohydrate-based cancer vaccines: target cancer with sugar bullets. Glycoconjugate Journal, 2012, 29, 259-271.
17. Wei, Meng-Man; Wang, Yong-Shi; Ye, Xin-Shan. Carbohydrate-based vaccines for oncotherapy. Medicinal Research Reviews. 2018, 38, 1003-1026.
18. Zhang, Xiang; Xu, Cheng-Hao; Mo, Juan; Zheng, Xiu-Jing; Chen, Yan-Fang; Yang, An-Qi; Zhang, Yi-Heng; Wang, Peng-Yu; Yuan, Xia; Ye, Xin-Shan. Self-Assembled Core–Shell Nanoscale Coordination Polymer Nanoparticles Carrying a Sialyltransferase Inhibitor for Cancer Metastasis Inhibition. ACS Applied Materials & Interfaces, 2023, 15, 7713-7724.
19. Guo, Jian; Li, Wenming; Xue, Weiwei; Ye, Xin-Shan. Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide. Journal of Medicinal Chemistry, 2017, 60, 2135-2141.
20. Li, Wenming; Niu, Youhong; Xiong, De-Cai; Cao, Xiaoping; Ye, Xin-Shan. Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors. Journal of Medicinal Chemistry, 2015, 58, 7972-7990.
21. Wang, Xiaofang; Zhang, Li-He; Ye, Xin-Shan. Recent development in the design of sialyltransferase inhibitors. Medicinal Research Reviews, 2003, 23, 32-47.
22. Li, Gefei; Ma, Wenxiao; Mo, Juan; Cheng, Boyang; Shoda, Shin-ichiro; Zhou, Demin; Ye, Xin-Shan. Influenza Virus Precision Diagnosis and Continuous Purification Enabled by Neuraminidase-Resistant Glycopolymer-Coated Microbeads. ACS Applied Materials & Interfaces, 2021, 13, 46260-46269.
23. Niu, Youhong; Wang, Minghui; Cao, Yafei; Nimmagadda, Alekhya; Hu, Jianxing; Wu, Yanfen; Cai, Jianfeng; Ye, Xin-Shan. Rational Design of Dimeric Lysine&IT N&IT-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents. Journal of Medicinal Chemistry, 2018, 61, 2865-2874.
24. Yang, An-Qi; Li, Daoyuan; Chi, Lianli; Ye, Xin-Shan. Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP). Molecular & Cellular Proteomics, 2017, 16, 1233-1243.
25. Wang, Guan-Nan; Reinkensmeier, Gabriele; Zhang, Si-Wei; Zhou, Jian; Zhang, Liang-Ren; Zhang, Li-He; Butters, Terry D.; Ye, Xin-Shan. Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease. Journal of Medicinal Chemistry, 2009, 52, 3146-3149.
26. Ye, Xin-Shan; Sun, Fang; Liu, Min; Li, Qin; Wang, Yuhang; Zhang, Guisheng; Zhang, Li-He; Zhang, Xiao-Lian. Synthetic iminosugar derivatives as new potential immunosuppressive agents. Journal of Medicinal Chemistry, 2005, 48, 3688-3691.