CV - Prof. Xin-Shan Ye

Prof. Xin-Shan Ye

Organic Chemistry; Medicinal Chemistry; Chemical Glycobiology

 

CONTACT INFORMATION

Work Address: School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd No. 38, Beijing 100191, China

Telephone/Fax: +86-10-82805736

E-mail: xinshan@bjmu.edu.cn

• B.Sc.          Wuhan University, 1981-1985

• M. Sc.         Wuhan University, 1985-1988 (supervised by Prof. Cheng-Tai Wu, Synthesis of crown ether compounds)

• Ph.D.          The Chinese University of Hong Kong, 1993-1996 (supervised by Prof. Henry N. C. Wong, Synthesis of 3,4-disubstituted thiophenes)

• Lecturer                           Huazhong Agricultural University, 1988-1993

• Research Associate         The Scripps Research Institute, USA, 1996-2000 (under the direction of Prof. Chi-Huey Wong, Synthesis of oligosaccharide library)

• Professor                          Peking University, 2000-
 

• Cheung Kong Scholars Programme Professionship (2000)

• National Outstanding Young Investigator Award by Natural Science Foundation of China (2005)

• Director of the State Key Laboratory of Natural and Biomimetic Drugs (2005-present)

• Natural Science Award of Ministry of Education, China, Second Class (2010)

• WuXi PharmaTech Life Science and Chemistry Award, Second Class (2010)

• Science and Technology Award of Chinese Pharmaceutical Association, First Class (2011)

• Development of new methodologies or strategies for the assembly of oligosaccharides.

• Synthesis and evaluation of biologically important oligosaccharides such as tumor-associated antigens.

• Design, synthesis and evaluation of carbohydrate-processing enzyme inhibitors as well as discovery of new carbohydrate-based drugs.

• Chemical modifications of aminoglycoside antibiotics.

• Co-Editors-in-Chief of Current Topics in Medicinal Chemistry (2014-)

• Member of International Advisory Board of ChemMedChem (2014-)

• Member of Editorial Board of Carbohydrate Research (2009-)

• Member of Editorial Board of Chinese Journal of Organic Chemistry (2007-)

• Member of Editorial Board of Chemical Journal of Chinese Universities (2007-)

• Member of Editorial Board of Chinese Journal of Medicinal Chemistry (2006-)

• Member of Editorial Board of Chinese Journal of New Drugs (2009-)

• Member of Editorial Board of Acta Scientiarum Naturalium Universitatis Pekinensis (2005-)

• Associate Editor-in-Chief of Journal of Chinese Pharmaceutical Sciences (2005-)

1. C.-H. Wong, Z. Zhang, I. Ollmann, T. Baasov and X.-S. Ye, "Programmable One-Pot Oligosaccharide Synthesis and Structural Effects of Monosaccharides on the Anomeric Glycosylation Reactivity", PCT Int. Appl. (2000), 109 pp. CODEN: PIXXD2 WO 0009527 Al 20000224; US patent No.: US 6,538,117 B1.

2. Xin-Shan Ye, Xiao-Lian Zhang, Fang Sun, Li-He Zhang, “Iminosugar derivatives: their synthesis and applications as immunosuppressive agents and glycosidase inhibitors”, Chinese patent No.: ZL 03 1 56099.7, Sept. 1, 2003.

3. Xin-Shan Ye, Yuhang Wang, Li-He Zhang, “Synthesis of the pentasaccharide antigen against hyper-rejection in organ xeno-transplantation”, Chinese patent No.: ZL 2004 1 0050073.8, July 2, 2004.

4. Xin-Shan Ye, Xuefei Huang, Qingyan Yan, Li-He Zhang, “Tri- and penta-saccharide antigens: their synthesis and applications as anti-immunorejection drugs”, Chinese patent No.: ZL 03 1 56098.9, Sept. 1, 2003.

5. Xin-Shan Ye, Jian Zhou, Li-He Zhang, Xiao-Lian Zhang, “A type of N-alkylated 1,6-dideoxyiminosugar derivatives: their synthesis and applications”, Chinese patent No.: ZL 2005 1 0109138.6, Oct. 18, 2005

1. Liu, Kai-Meng; Wang, Peng-Yu; Guo, Zhen-Yan; Xiong, De-Cai; Qin, Xian-Jin; Liu, Miao; Liu, Meng; Xue, Wan-Ying; Ye, Xinshan. Iterative Synthesis of 2-Deoxyoligosaccharides Enabled by Stereoselective Visible-Light Promoted Glycosylation. Angewandte Chemie International Edition, 2022, DOI: 10.1002/anie.202114726.

2. Li, Gefei; Ma, Wenxiao; Mo, Juan; Cheng, Boyang; Shoda, Shin-ichiro; Zhou, Demin; Ye, Xin-Shan. Influenza Virus Precision Diagnosis and Continuous Purification Enabled by Neuraminidase-Resistant Glycopolymer-Coated Microbeads. ACS Applied Materials & Interfaces, 2021, 13, 46260-46269.

3. Liu, Mingli; Qin, Xianjin; Ye, Xin-Shan. Glycan Assembly Strategy: From Concept to Application. Chemical Record, 2021, 21, 3256-3277.

4. Wu, Xiangyang; Wu, Yong; Zheng, Ruijuan; Tang, Fen; Qin, Lianhua; Lai, Detian; Zhang, Lu; Chen, Lingming; Yan, Bo; Yang, Hua; Wang, Yang; Li, Feifei; Zhang, Jinyu; Wang, Fei; Wang, Lin; Cao, Yajuan; Ma, Mingtong; Liu, Zhonghua; Chen, Jianxia; Huang, Xiaochen; Wang, Jie; Jin, Ruiliang; Wang, Peng; Sun, Qin; Sha, Wei; Lyu, Liangdong; Moura-Alves, Pedro; Dorhoi, Anca; Pei, Gang; Zhang, Peng; Chen, Jiayu; Gao, Shaorong; Randow, Felix; Zeng, Gucheng; Chen, Chang; Ye, Xin-Shan; Kaufmann, Stefan H. E.; Liu, Haipeng; Ge, Baoxue. Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. EMBO Reports, 2021, 22, e51678.

5. Qin, Xianjin; Ye, Xin-Shan. Donor Preactivation-Based Glycosylation: An Efficient Strategy for Glycan Synthesis. Chinese Journal of Chemistry, 2021, 39, 531-542.

6. Li, Bo-Han; Ye, Xin-Shan. Recent advances in glycan synthesis. Current Opinion in Chemical Biology, 2020, 58, 20-27.

7. Liu, Miao; Liu, Kai-Meng; Xiong, De-Cai; Zhang, Hanyu; Li, Tian; Li, Bohan; Qin, Xianjin; Bai, Jinhe; Ye, Xin-Shan. Stereoselective Electro-2-deoxyglycosylation from Glycals. Angewandte Chemie International Edition, 2020, 59, 15204-15208.

8. Li, Bo-Han; Yao, Wenlong; Yang, Hong; Wu, Congying; Xiong, De-Cai; Yin, Yuxin; Ye, Xin-Shan. Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation. Organic Chemistry Frontiers, 2020, 7, 1255-1259.

9. Wang, Yong-Shi; Wu, Yong; Xiong, De-Cai; Ye, Xin-Shan. Total Synthesis of a Hyperbranched N-Linked Hexasaccharide Attached to ATCV-1 Major Capsid Protein without Precedent. Chinese Journal of Chemistry, 2019, 37, 42-48.

10. Wang, Dong; Xiong, De-Cai; Ye, Xin-Shan. A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM5). Chinese Chemical Letters, 2018, 29, 1340-1342.

11. Zhang, Gao-Lan; Wei, Meng-Man; Song, Chengcheng; Ma, Yu-Feng; Zheng, Xiu-Jing; Xiong, De-Cai; Ye, Xin-Shan. Chemical synthesis and biological evaluation of penta- to octa-saccharide fragments of Vi polysaccharide from Salmonella typhi. Organic Chemistry Frontiers, 2018, 5, 2179-2188.

12. Tang, Shengbiao;  Zheng, Qiannan; Xiong, De-Cai; Jiang, Shende; Li, Qin; Ye, Xin-Shan. Stereocontrolled Synthesis of 2-Deoxy-C-glycopyranosyl Arenes Using Glycals and Aromatic Amines. Organic Letters, 2018, 20, 3079-3082.

13. Zhang, Gao-Lan; Ye, Xin-Shan. Synthetic Glycans and Glycomimetics: A Promising Alternative to Natural Polysaccharides. Chemistry A European Journal, 2018, 24, 6696-6704.

14. Wei, Meng-Man; Wang, Yong-Shi; Ye, Xin-Shan. Carbohydrate-based vaccines for oncotherapy. Medicinal Research Reviews. 2018, 38, 1003-1026

15. Niu, Youhong; Wang, Minghui; Cao, Yafei; Nimmagadda, Alekhya; Hu, Jianxing; Wu, Yanfen; Cai, Jianfeng; Ye, Xin-Shan. Rational Design of Dimeric Lysine&IT N&IT-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents. Journal of Medicinal Chemistry, 2018, 61, 2865-2874.

16. Zhang, Gao-Lan; Yang, Lin; Zhu, Jingjing; Wei, Mengman; Yan, Wanjun; Xiong, De-Cai; Ye, Xin-Shan. Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from Salmonella typhi. Chemistry A European Journal, 2017, 23, 10670-10677.

17. Song, Chengcheng; Zheng, Xiu-Jing; Liu, Chang-Cheng; Zhou, Yifa; Ye, Xin-Shan. A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model. Oncotarget, 2017, 8, 47330-47343.

18. Zhang, Shuo; Niu, You-Hong; Ye, Xin-Shan. General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C H Functionalization Strategy. Organic Letters, 2017, 19, 3608-3611.

19. Yang, An-Qi; Li, Daoyuan; Chi, Lianli; Ye, Xin-Shan. Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP). Molecular & Cellular Proteomics, 2017, 16, 1233-1243.

20. Wu, Yong; Xiong, De-Cai; Chen, Si-Cong; Wang, Yong-Shi; Ye, Xin-Shan. Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units. Nature Communications, 2017, 8, 14851.

21. Guo, Jian; Li, Wenming; Xue, Weiwei; Ye, Xin-Shan. Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide. Journal of Medicinal Chemistry, 2017, 60, 2135-2141.

22. Yu, Yang; Xiong, De-Cai; Mao, Run-Ze; Ye, Xin-Shan. Visible Light Photoredox-Catalyzed O-Sialylation Using Thiosialoside Donors. Journal of Organic Chemistry, 2016, 81, 7134-7138.

23. Sun, Lifeng; Wu, Xiaowei; Xiong, De-Cai; Ye, Xin-Shan. Stereoselective Koenigs-Knorr Glycosylation Catalyzed by Urea. Angewandte Chemie International Edition, 2016, 55,  8041-8044.

24. Liu, Chang-Cheng; Zhai, Canjia; Zheng, Xiu-Jing; Ye, Xin-Shan. Altering the Specificity of the Antibody Response to HIV gp120 with a Glycoconjugate Antigen. ACS Chemical Biology, 2016, 11, 1702-1709.

25. Liu, Minglong; Niu, Youhong; Wu, Yan-Fen; Ye, Xin-Shan. Ligand-Controlled Monoselective C-Aryl Glycoside Synthesis via Palladium-Catalyzed C-H Functionalization of N-Quinolyl Benzamides with 1-lodoglycals. Organic Letters, 2016, 18, 1836-1839.

26. Tang, Shengbiao; Xiong, De-Cai; Jiang, Shende; Ye, Xin-Shan. Nitro-polyols via Pyridine Promoted C=C Cleavage of 2-Nitroglycals. Application to the Synthesis of (-)-Hyacinthacine A1. Organic Letters, 2016, 18, 568-571.

27. Mao, Run-Ze; Xiong, De-Cai; Guo, Fan; Li, Qin; Duan, Jinyou; Ye, Xin-Shan. Light-driven highly efficient glycosylation reactions. Organic Chemistry Frontiers, 2016, 3, 737-743.

28. Mao, Run-Ze; Guo, Fan; Xiong, De-Cai; Li, Qin; Duan, Jinyou; Ye, Xin-Shan. Photoinduced C-S Bond Cleavage of Thioglycosides and Glycosylation. Organic Letters, 2015, 17, 5606-5609.

29. Wang, Bang; Xiong, De-Cai; Ye, Xin-Shan. Direct C-H Trifluoromethylation of Glycals by Photoredox Catalysis. Organic Letters, 2015, 17, 5698-5701.

30. Li, Wenming; Niu, Youhong; Xiong, De-Cai; Cao, Xiaoping; Ye, Xin-Shan. Highly Substituted Cyclopentane-CMP Conjugates as Potent Sialyltransferase Inhibitors. Journal of Medicinal Chemistry, 2015, 58, 7972-7990.

31. Liu, Ying-Guo; Li, Xiaxi; Xiong, De-Cai; Yu, Binhan; Pu, Xiaoping; Ye, Xin-Shan. Synthetic phenylethanoid glycoside derivatives as potent neuroprotective agents. European Journal of Medicinal Chemistry, 2015, 95, 313-323.

32. Li, Qin; Ye, Xin-Shan. Iminosugars as Immunomodulating Agents: Synthesis and Biological Activities of 1-Deoxynojirimycin and Related Compounds. Israel Journal of Chemistry, 2015, 55, 336-346.

33. Wu, Xiaowei; Zhang, Fu-Yu; Zhu, Jingjing; Song, Chengcheng; Xiong, De-Cai; Zhou, Yifa; Cui, Yuxin; Ye, Xin-Shan. N-Arylated-Lactam-Type Iminosugars as New Immunosuppressive Agents: Discovery, Optimization, and Biological Evaluation. Chemistry An Asian Journal, 2014, 9, 2260-2271.

34. Xu, Fei-Fei; Wang, Yue; Xiong, De-Cai; Ye, Xin-Shan. Stereoselective Synthesis of the Trisaccharide Moiety of Ganglioside HLG-2. Journal of Organic Chemistry, 2014, 79, 797-802.

35. Liu, Chang-Cheng; Ye, Xin-Shan. Carbohydrate-based cancer vaccines: target cancer with sugar bullets. Glycoconjugate Journal, 2012, 29, 259-271.

36. Han, Ming-Jie; Xiong, De-Cai; Ye, Xin-Shan. Enabling Wittig reaction on site-specific protein modification. Chemical Communications, 2012, 48, 11079-11081.

37. Yang, Lin; Zhu, Jingjing; Zheng, Xiu-Jing; Tai, Guihua; Ye, Xin-Shan. A Highly alpha-Stereoselective Synthesis of Oligosaccharide Fragments of the Vi Antigen from Salmonella typhi and Their Antigenic Activities. Chemistry A European Journal, 2011, 17, 14518-14526.

38. Wang, Guan-Nan; Yang, Lin; Zhang, Li-He; Ye, Xin-Shan. A Versatile Approach to N-Alkylated 1,4-Dideoxy-1,4-imino-D-arabinitols and 1,4-Dideoxy-1,4-imino-L-xylitols. Journal of Organic Chemistry, 2011, 76, 2001-2009.

39. Yang, Fan; Zheng, Xiu-Jing; Huo, Chang-Xin; Wang, Yue; Zhang, Ye; Ye, Xin-Shan. Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen. ACS Chemical Biology, 2011, 6, 252-259.

40. Wang, Guan-Nan; Reinkensmeier, Gabriele; Zhang, Si-Wei; Zhou, Jian; Zhang, Liang-Ren; Zhang, Li-He; Butters, Terry D.; Ye, Xin-Shan. Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease. Journal of Medicinal Chemistry, 2009, 52, 3146-3149.

41. Xiong, De-Cai; Zhang, Li-He; Ye, Xin-Shan. Oxidant-Controlled Heck-Type C-Glycosylation of Glycals with Arylboronic Acids: Stereoselective Synthesis of Aryl 2-Deoxy-C-glycosides. Organic Letters, 2009, 11, 1709-1712.

42. Lu, Yin-Suo; Li, Qin; Zhang, Li-He; Ye, Xin-Shan. Highly direct alpha-selective Glycosylations of 3,4-O-carbonate-protected 2-deoxy- and 2,6-dideoxythioglycosides by preactivation protocol. Organic Letters, 2008, 10, 3445-3448.

43. Xiong, De-Cai; Zhang, Li-He; Ye, Xin-Shan. Bromodimethylsulfonium bromide-silver triflate: A new powerful promoter system for the activation of thioglycosides. Advanced Synthesis & Catalysis, 2008, 350, 1696-1700.

44. Geng, Yiqun; Zhang, Li-He; Ye, Xin-Shan. Pre-activation protocol leading to highly stereoselectivity-controllable glycosylations of oxazolidinone protected glucosamines. Chemical Communications, 2008, 597-599.

45. Fan, Qiu-Hua; Ni, Nan-Ting; Li, Qin; Zhang, Li-He; Ye, Xin-Shan. New One-Carbon Degradative Transformation of b-Alkyl-b-azido Alcohols. Organic Letters, 2006, 8, 1007-1009.

46. Wang, Yuan; Li, Qin; Cheng, Shui-Hong; Wu, Yan-Fen; Guo, Dong-Jie; Fan, Qiu-Hua; Wang, Xiao-Fang; Zhang, Li-He; Ye, Xin-Shan. Base-promoted rearrangement of sugar epoxides to unsaturated sugars. Organic Letters, 2005, 7, 5577-5579.

47. Ye, Xin-Shan; Sun, Fang; Liu, Min; Li, Qin; Wang, Yuhang; Zhang, Guisheng; Zhang, Li-He; Zhang, Xiao-Lian. Synthetic iminosugar derivatives as new potential immunosuppressive agents. Journal of Medicinal Chemistry, 2005, 48, 3688-3691.

48. Wang, Yuhang; Huang, Xuefei; Zhang, Li-He; Ye, Xin-Shan. A four-component one-pot synthesis of α-Gal pentasaccharide. Organic Letters, 2004, 6, 4415-4417.

49. Huang, Xuefei; Huang, Lijun; Wang, Haisheng; Ye, Xin-Shan. Iterative one-pot synthesis of oligosaccharides. Angewandte Chemie International Edition, 2004, 43, 5221-5224.

50. Wang, Xiaofang; Zhang, Li-He; Ye, Xin-Shan. Recent development in the design of sialyltransferase inhibitors. Medicinal Research Reviews 2003, 23, 32-47.