当前位置：首页 > 周德敏课题组 > English
English

Demin Zhou，Ph.D, Professor

                                                                                              2-周老师头像.jpg

Director of State Key Laboratory of Natural and Biomimetic Drugs

Dean of school of Pharmaceutical Sciences

Chang Jiang Scholars

Tel: 8610-8280-5857

E-mail: deminzhou@bjmu.edu.cn

Education

1985-1990  B.Sc., School of Pharmaceutical Sciences, Beijing Medical University, China

1990-1996  Joint Ph.D., Medicinal Chemistry, Beijing Medical University (China) and University of Tsukuba (Japan)

                   (supervised by Prof. Li-He Zhang and Kazunari Taira)

1999-2002  Postdoctoral, Department of Chemistry, University of California at Berkeley/The Scripps Research Institute，USA

                  (supervised by Prof. Peter G. Schultz)

Professional Experience

u  1996.08-1998.12 Assistant Professor, Department of Applied Biochemistry, University of Tsukuba, Japan

u  2002.04-2003.04 Senior Scientist, Chugai Pharmaceuticals Inc., California, USA

u  2003.05-2008.08 Group Leader and Division Head, Immusol Inc., California, USA

u  2008.09-present  Professor, School of Pharmaceutical Sciences, Peking University Health Science Center, China

u  2012--present, Director of  State Key Laboratory of Natural and Biomimetic Drugs

u  2016--present, Dean of school of Pharmaceutical Sciences

Awards and Honors

u  1990 Japanese Government Scholarship 

u  1996 The First National Excellent Doctorial Dissertation

u  1999 The First Prize  of Science and Technology Progress, awarded by People's Republic of China State Education Commission

u  2002 Chugai-Roche Outstanding Contribution Award

u  2002 Immusol  Outstanding Contribution Award

u  2004 The Second Prize of National Award for Natural Sciences, awarded by People's Republic of China

Research Interests

u  Biotechnology development

u  Target discovery and development

u  Antiviral and anticancer drug development

Publication 

  1. Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem. 2019, 166, 328-338
  2. Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem. 2019, 163, 560-568.
  3. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv. 2018, 11(4), aau8408
  4. Zhang C,* Zhou D.* Chemical modification strategies of viral vectors for gene therapy. Sci China-Chem.; 2018, 48 (11), 1365-1375
  5. Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. China-Chem.; 2018, 48(11) , 589-599
  6. Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett. 2018, doi: https://doi.org/10.1016/j.cclet.2018.10.009
  7. Zhang C*, Zhou X, Yao T, Tian Z, Zhou D*. Precision fluorescent labeling of an adeno-associated virus vector to monitor the viral infection pathway. Biotechnol J. 2018, 13(4), e1700374.
  8. Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem.; 2018, 146, 194-205.
  9. Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med. Res. Rev. 2018, 38(3), 951-976.
  10. Wang Y,# Wu X,# Du M, Chen X, Ning X, Chen H, Wang S, Liu J, Liu Z, Li R, Fu G, Wang C, McNutt MA, Zhou D,* Yin Y.* Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation. Oncotarget. 2017, 8(26), 42510-42524
  11. Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem. 2017, 35(8), 1322-1328
  12. Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q,* Zhou D.* Redirecting Killer T Cells through Incorporation of Azido Sugars for Tethering Ligands. Chembiochem. 2017, 18(21), 2082-2086.
  13. Zhang Z, Xu H, Si L, Chen Y, Zhang B, Wang Y, Wu Y, Zhou X, Zhang L, Zhou D.* Construction of an inducible stable cell line for efficient incorporation of unnatural amino acids in mammalian cells. Biochem Biophys Res Commun. 2017, 489(4), 490-496.
  14. Zhang C,#,* Lu J,# Su H, Yang J, Zhou D.* Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions. Sci. Rep. 2017, 7, 46569
  15. Yao T,# Zhou X,# Zhang C,* Yu X, Tian Z, Zhang L, Zhou D.* Site-specific PEGylated adeno-associated viruses with increased serum stability and reduced immunogenicity. Molecules 2017, 22(7), 1155
  16. Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y, Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity. MedChemComm. 2017, 8, 1531-1541
  17. Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y, Zhou D, Xiao S.* Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules 2017, 22(7), 1018
  18. Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D, Xiao S.*  Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem. 2017,134, 133-139
  19. Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron 2017, 73 (17), 2512-2517. （"Front Cover Article"）
  20. Wu S, Yang L, Sun W, Si L, Xiao S, Wang Q, Dechoux L, Thorimbert S, Sollogoub M, Zhou D, Zhang Y.* Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem.; 2017, 130, 308-319.
  21. Wu L,# Chen J,# Wu Y,# Zhang B, Cai X, Zhang Z, Wang Y, Si L, Xu H, Zheng Y, Zhang C, Liang C, Li J, Zhang L, Zhang Q, Zhou D.* Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone. J. Control Release, 2017, 249, 84-93.
  22. Si L,# Xu H,# Zhou X, Zhang Z, Tian Z, Zhang B, Niu Z, Yao T, Wang Y, Li S, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines.  Science 2016, 354(6316), 1170-1173.
  23. Zhang C, Yao T, Zheng Y, Li Z, Zhang L, Zhou D*. Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification. Data Brief. 2016, 7, 77-80.
  24. Wu Y,# Zhu H,# Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z,* Zhou D.* Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjugate Chem.; 2016, 27(10), 2460-2468
  25. Xiao S,* Wang Q, Si L, Zhou X, Zhang Y, Zhang L, Zhou D.* Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors. Eur. J. Med. Chem.; 2016, 124, 1-9
  26. Han X, Shi Y, Si L, Fan Z, Wang H, Xu R, Jiao P, Meng K, Tian Z, Zhou X, Jin H, Wu X, Chen H, Zhang Y, Zhang L, Xiao S,* Zhou D.* Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors. MedChemComm.; 2016, 7, 1932-1945 ("HOT" Article)
  27. Yu F,* Wang Q, Wang H, Si L, Liu J, Han X, Xiao S, Zhang L, Zhou D.* Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chin. Chem. Lett.; 2016, 27, 711-713
  28. Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Xiao S, Zhang L, Xia Q,* Zhou D.* Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem.; 2016, 17, 1-8.
  29. Han Wang, Renyang Xu, Yongying Shi, Longlong Si, Pingxuan Jiao, Zibo Fan, Xu Han, Xingyu Wu, Xiaoshu Zhou, Fei Yu, Yongmin Zhang, Lihe Zhang, Demin Zhou*, Sulong Xiao*. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur. J. Med. Chem.; 2016, 110, 376-388
  30. Fei Yu,* Yongxiang Zheng, Yiyun Peng, Demin Zhou, Sulong Xiao.* Design and synthesis of ring A and/or C expansion and opening oleanolic acid derivatives. Chin. J. Org. Chem.; 2016, 36, 512-519
  31. Bo Zhang, Qi Yang, Jingxian Chen, Ling Wu, Tianzhuo Yao, Yiming Wu, Huan Xu, Lihe Zhang, Qing Xia*, Demin Zhou*. CRISPRi-manipulation of genetic code expansion via RF1 for reassignment of amber codon in bacteria. Sci. Rep.; 2016, 6, 20000
  32. Chuanling Zhang, Tianzhuo Yao, Yongxiang Zheng, Zhongjun Li, Lihe Zhang, Demin Zhou*. Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery. Biomaterials. 2016, 80: 134-145.
  33. Sulong Xiao,* Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu, Yongmin Zhang, Lihe Zhang, Demin Zhou*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials. 2016, 78, 74-85.
  34. Siwen Niu, Longlong Si, Dong Liu, Andrew Zhou, Ziwei Zhang, Zongze Shao, Shaomeng Wang, Lihe Zhang, Demin Zhou,* Wenhan Lin.* Spiromastilactones: a new class of influenza virus inhibitors from deep-sea fungus. Eur. J. Med. Chem. 2016, 102, 594-599.
  35. Wang Q, Qiao X, Qian Y, Li ZW, Tzeng YM, Zhou DM*, Guo DA, Ye M*. Intestinal Absorption of Ergostane and Lanostane Triterpenoids from Antrodia cinnamomea Using Caco-2 Cell Monolayer Model. Nat. Prod. Bioprospect. 2015, 5(5): 237-246
  36. Shuai Ji, Ru Li, Qi Wang,Wen-juan Miao,Zi-wei Li, Long-long Si, Xue Qiao, Si-wang Yu, De-min Zhou,* Min Ye.* Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. Journal of Ethnopharmacology. 2015, 176, 475-484
  37. Wen Shi, Jing Yang (Co-first author), Siyuan Li, Xiaofeng Shan, Xiaosong Liu, Hong Hua, Chuanke Zhao, Zhendong Feng, Zhigang Cai, Lihe Zhang, Demin Zhou.* Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget. 2015, 6(37): 40172-40185.
  38. 肖苏龙, 王晗, 王琪, 韩旭, 徐仁洋, 孟坤, 田振宇, 张礼和, 周德敏.* 基于五环三萜先导结构的抗病毒抑制剂研究进展. 中国科学(化学). 2015, 45(9): 865-883
  39. Han Wang, Fei Yu, Yiyun Peng, Qi Wang, Xu Han, Renyang Xu, Xiaoshu Zhou, Chuanxing Wan, Zibo Fan, Pingxuan Jiao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao.* Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European Journal of Medicinal Chemistry. 2015, 102: 594-599
  40. Bo Zhang, Huan Xu, Jingxian Chen, Yongxiang Zheng, Yiming Wu, Longlong Si, Ling Wu, Chuanling Zhang, Gang Xia, Lihe Zhang, and Demin Zhou*. Development of next generation of therapeutic IFN-alpha2b via genetic code expansion. Acta Biomaterialia. 2015, 9: 100-111
  41. Zheng, Yongxiang; Yu, Fei; Wu, Yiming; Si, Longlong; Xu, Huan; Zhang, Chuanling; Xia, Qing; Xiao, Sulong; Wang, Qi; He, Qiuchen; Chen, Peng; Wang, Jiangyun; Zhang, Li He;* Taira, Kazunari; Zhou, Demin.* Broaden the versatility of lentiviral vector as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res., 2015, 43(11):e73
  42. Xueqing Chen, Longlong Si (Co-first author), Dong Liu, Peter Proksch, Lihe Zhang, Demin Zhou,* Wenhan Lin.* Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur. J. Med. Chem., 2015, 93: 182-195.
  43. Maorong Yu, Longlong Si, Yufei Wang, Yiming Wu, Fei Yu, Pingxuan Jiao, Yongying Shi, Han Wang, Sulong Xiao, Ge Fu, Ke Tian, Yitao Wang, Zhihong Guo, Xinshan Ye, Lihe Zhang and Demin Zhou.* Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses. J. Med. Chem. 2014, 57(23): 10058-10071
  44. Yingbo Li, Jinxi Wang, Xing Gao, Weihua Han, Yongxiang Zheng, Huan Xu, Chuanling Zhang, Qiuchen He, Lihe Zhang, Zhongxin Li* and Demin Zhou*. c-Met targeting enhances the effect of irradiation and chemical agents against malignant colon cells harboring a KRAS mutation. PlosOne. 2014. 9(11): e113186
  45. Wei Xiong, Jing Zhao, Hongliang Yu, Xiaoying Li, Shaoqian Sun, Yi Li, Qing Xia, Chuanling Zhang, Qiucheng He, Xianshu Gao, Lihe Zhang, Demin Zhou.* Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress. PlosOne. 2014. 9(11): e111191
  46. Zhendong Feng, Wen Shi, Zhigang Cai, Hong Hua, Demin Zhou*. Detection of microRNA expressions in tissues and exfoliative cells reveals the potential role of miR-203 in oral lichen planus. Journal of Chinese Pharmaceutical Sciences. 2014, 23 (5), 279-286.
  47. Zhang, Jinming; Li, Yingbo; Fang, Xiefan; Zhou, Demin; Wang, Yitao; Chen, Meiwan.* TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. International Journal of Pharmaceutics (Amsterdam, Netherlands). 2014, 476(1-2), 185-198.
  48. Junfeng Wang, Yingbo Li, Nikul G. Patel, Ge Zhang, Demin Zhou, Yi Pang*. A single molecular probe for multi-analyte (Cr3+, Al3+ and Fe3+) detection in aqueous medium and its biological application. Chemical Communications. 2014, 50(82), 12258-12261.
  49. Wang, Qian; Sun, Tingting; Xu, Jianfeng; Shen, Zhouxin; Briggs, Steven P.; Zhou, Demin; Wang, Lei. Response and Adaptation of Escherichia coli to Suppression of the Amber Stop Codon. ChemBioChem. 2014, 15 (12), 1744-1749.
  50. Song, Wei; Si, Longlong; Ji, Shuai; Wang, Han; Fang, Xiao-mei; Yu, Li-yan; Li, Ren-yong; Liang, Lina; Zhou, Demin; Ye, Min. Uralsaponins M-Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis. Journal of Natural Products. 2014, 77(7), 1632-1643.
  51. Wang, Junfeng; Li, Yingbo; Duah, Ernest; Paruchuri, Sailaja; Zhou, Demin; Pang, Yi. A selective NIR-emitting zinc sensor by using Schiff base binding to turn-on excited-state intramolecular proton transfer. Journal of Materials Chemistry B: Materials for Biology and Medicine. 2014, 2(14), 2008-2012.
  52. Sulong Xiao, Qi Wang, Longlong Si, Yongying Shi, Han Wang, Fei Yu, Yongmin Zhang, Yingbo Li, Yongxiang Zheng, Chuanling Zhang, Chunguang Wang, Lihe Zhang, Demin Zhou.* Synthesis and anti-HCV entry activity studies of new β-cyclodextrin-pentacyclic triterpene conjugates. ChemMedChem., 2014, 9(5): 1060-1070.
  53. Fei Yu, Yiyun Peng, Qi Wang, Yongying Shi, Longlong Si, Han Wang, Yongxiang Zheng, Emily Lee, Sulong Xiao, Maorong Yu, Yingbo Li, Chuanling Zhang, Hengli Tang, Chunguang Wang, Lihe Zhang, and Demin Zhou,* Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors. Eur. J. Med. Chem., 2014, 77: 258-268.
  54. Aigang Yang, Longlong Si, Zhenping Shi, Li Tian, Dong Liu, Demin Zhou, Peter Proksch, and Wenhan Lin. Nitrosporeusines A and B, Unprecedented Thioester-Bearing Alkaloids from the Arctic Streptomyces nitrosporeus. Org. Lett.; 2013, 15(20): 5366-5369.
  55. Fe Yu, Qi Wang, Zhen Zhang, Yiyun Peng, Yongying Shi, Yongxiang Zheng, Sulong Xiao,* Han Wang, Yongyan Qiu, Xiaoxi Huang, Chuanke Zhao, Chuanling Zhang, Dian Sun, Lihe Zhang and Demin Zhou*. Development of oleanane-type triterpene as a new class of HCV entry inhibitors. J. Med. Chem. 2013, 56(11): 4300-4319.
  56. Li YB, Wang ZQ, Yan X, Chen MW, Bao JL, Wu GS, Ge ZM, Zhou DM, Wang YT, Li RT. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer lett., 2013, 340(1):88-96.
  57. Sulong Xiao, Ming Yang, Fei Yu, Lihe Zhang, Demin Zhou*, Pierre Sinaÿ, Yongmin Zhang.* Synthesis of four mono-functionalized α-cyclodextrin derivatives for further confirming DIBAL-H-promoted bis-de-O-methylation mechanism. Tetrahedron. 2013, 69(20): 4053-4060.
  58. Peng Zhang, Xiaoyan Liu, Yuanjun Zhu, Shizhong Chen, Demin Zhou and Yinye Wang. Honokiol inhibits the inflammatory during cerebral ischemia reperfusion through suppressing NF-kB activation and cytokine production of glial cells. Neuroscience Lett. 2013, 534: 123-127.
  59. Wang H., Xiao SL., Wang Q., Sun DA., Ye M., Zhang LH., Zhou DM*. Elucidation of the pharmacophore of echinocystic acid as a new lead for blocking HCV entry. Eur. J. Med. Chem. 2013, 64: 160-168.
  60. Hongliang Yu, Xiaoying Li, Shaoqian Sun, Xianshu Gao, Demin Zhou*. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Biochem. Biophys. Res. Comm. 2012, 427: 659-665.
  61. Xiao SL, Wang Q, Yu F, Peng YY, Zhou DM*. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorg. Med. Chem. 2012, 20(18): 5616-5622.
  62. Jin X. and Zhou DM*. Strand antagonism in RNAi: An explanation of potency variation of dsRNA versus shRNA generated intracellularly. Nucleic Acd. Res. 2012, 40(4): 1797-1806.
  63. Xiao, S, Zhou DM and Zhang Y. Facile preparation of two tetrols from permethylated α-cyclodextrin and unambiguous NMR analysis. Tetrahedron Lett. 2011, 52(41): 5273-5276.
  64. Zhou DM*, Zhang J, Wang CY and Wong-staal F, A method for detecting and preventing negative RNA interference in preparation of lentiviral vector for siRNA delivery. RNA. 2009, 15: 732-740.
  65. Yu D, Macdonald J, Liu G, Ke N, Zhou DM, Wong-Staal F. Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS ONE, 2008: e3951.
  66. He QC, Tang HL, Zhang J, Wong-Staal F and Zhou DM*. Comparison of RNAi approaches for validation of human RNA helicase A as an essential factor in hepatitis C virus replication. J Viro Methods. 2008, 154: 216-219.
  67. Zhou DM*, Wang CY, Zhang J, Ke N, Bliesath J and Wong-staal F. Generation of shRNA pool library: revise the biological technique from the viewpoint of chemistry. ChemBioChem 2008, 9: 1365-1367.
  68. Zhang J, Wang CY, Ke N, Bliesath J, Chatterton JE, Wong-Staal F and Zhou DM*. A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. RNA. 2007, 13: 1375-1383.
  69. Ke, N., Zhou DM, Chatterton JE, Liu GH, Chionis J, Zhang J, Tsugawa L, Lynn R, Yu DH, Meyhack B, Wong-Staal F, Li QX, A new inducible RNAi xenograft model for assessing the staged tumor response to mTOR silencing. Exp Cell Res. 2006, 312: 2726-2734.
  70. Zhou DM*, He, QC, Zhang J, Wang CY and Wong-staal F, “RNA interference and potential applications”, Cur Topic in Med Chem. 2006, 6, 901-911.
  71. Ke, N., Zhou DM, Fan WF, Chatterton JE, Sundaram R, Chionis J, Zhang J, Hu XY, Yu DH, Awald T, Meyhack B, Brachat A, Paoni NF, Wong-Staal F, Li HQ. Discovery and in vivo validation of novel cancer targets of orphan receptor and protein kinase using inducible RNAi xenograft models. Clinical Cancer Research. (2006) 11(24), 9164.
  72. Zhou DM, Yuen P, Chu D, Thon V, McConnell S, Brown S, Tsang A, Pena M, Russell A, Cheng JF, Nadzan AM, Barbosa MS, Dyck JRB, Lopaschuk GD, Yang G, “Expression, purification and characterization of human malonyl-CoA decarboxylase”, Protein expression & purification, (2004) 34, 261-269.
  73. Zheng LX, Liu J, Zhou DM, Orth A, Ding S and Schultz PG, “An approach to genomewide screens of expressed small interfering RNAs in mammalian cells”, Proc. Natl. Acad. Sci. USA, (2004) 101, 135-140.
  74. A. Wada, T. Shimayama, Zhou DM, M. Warashina, T. Koguma, & Taira, K. "Controlled Drug Delivery: The Next Generation", Park, K. (Ed.), ACS Professional Reference Book, American Chemical Society, Washington, DC, 357-385 (2003).
  75. Zhou DM, et al. “Existence of efficient divalent-metal-ion-catalyzed and inefficient divalent-metal-ion-independent channels in reactions catalyzed by a hammerhead ribozyme”, Nucleic Acid Research, (2002) 30, 3300-5.
  76. Zhou DM Q. He, J. Zhou, T. Baba & K. Taira, "Comparison of the kinetic process of RNA cleavages by a DNA enzyme and RNA enzyme”. Biomacromolecules, (2002) 3, 69-83.
  77. Guo Z, Zhou DM and Schultz PG. “Designing small-molecule switches for protein-protein interactions”. Science,(2000) 288, 2042-2045.
  78. De-Min Zhou & Kazunari Taira, "The hydrolysis of RNA: from theoretical calculations to the ribozyme-mediated cleavage of RNA". Chem. Rev., (1998) 98, 991-1026.
  79. De-Min Zhou, Q. He, J. Zhou, K. Taira, Explanation by a putative triester-like mechanism for the thio effects and Mn2+ rescues in reactions catalyzed by a hammerhead ribozyme. FEBS Lett. (1998), 431(2), 154-160.
  80. De-Min Zhou, L. Zhang & K. Taira, "Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion-effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme". Proc. Natl. Acad. Sci. USA, (1997) 94, 14343-14348.
  81. De-Min Zhou, B. Yue, J. Cui, M. Cai & L. Zhang, "The Total Synthesis of Sinomendine and its analogs,"Heterocycles, (1997) 45, 439-450.
  82. P. Urvil, De-Min Zhou, K. Shimotohno, P. Kumar & S. Nishkawa, "Selection of RNA Aptamers that Bind Specifically to the NS3 Protease of Hepatitis C Virus," Eur. J. Biochem., (1997) 248, 130-138.
  83. M. Warashina, Y. Takagi, S. Sawata, De-Min Zhou & K. Taira, "Entropically driven enhancement of cleavage activity of a DNA-armed hammerhead ribozyme: mechanism of action of hammerhead ribozyme" J. Org. Chem. (1997), 62(26), 9138-9147.
  84. De-Min Zhou, R. Li, B. Yue & M. Cai, Friedel-0Crafts reaction of bromophenols. Huaxue TongBao, (1997) 5, 42-43.
  85. M. Warashina, S. Fujita, R. Utsunomiya, De-Min Zhou & K. Taira, Mechanism of action of a hammerhead ribozyme: a metalloenzyme,” J. Syn. Org. Chem. Japan, (1997) 55, 375-383.
  86. De-Min Zhou, L. Zhang, P. Kumar & K. Taira, "Ribozyme mechanism revisited: Evidence against direct coordination of a Mg2+ ion with the pro-R oxygen of the scissile phosphate in the transition state of a hammerhead ribozyme-catalyzed reaction" J. Am. Chem. Soc. (1996) 118, 8969-8970.
  87. De-Min Zhou, Nassim Usman, Li-He Zhang, Penmetcha K. R. Kumar & Kazunari Taira, "Evidence for the Rate-Limiting Departure of the 5'-Oxygen in Nonenzymatic and Hammerhead Ribozyme-Catalyzed reactions," J. Am. Chem. Soc., (1996) 118, 5862-5866.
  88. De-Min Zhou, L. Zhang, M. Orita, K. Yoshinari & K. Taira, "Magnesium-mediated cleavage of phosphorus-oxygen bond: a ribozyme reaction," Phosphorus, Sulfur, and Silicon, (1996) 108, 273-276.
  89. De-Min Zhou, T. Kohda, S. Koseki, K. Kokuma & K. Taira, "Mechanistic studies of hammerhead ribozymes and their applications in vivo," Biotechnologia, (1996) 4, 183-200.
  90. P. Kumar, De-Min Zhou, K. Yoshinari & K. Taira, “Mechanistic studies of hammerhead ribozymes,” Nucleic Acids and Molecular Biology, (1996) 10, 217-230

Books

  1. Xiong W, Sun TT, Jin X and LH Zhang, Zhou DM*. “Inducible RNAi and drug target validation”, in “Medicinal Chemistry of Nucleic Acids”, Zhang LH. Ed.; John Willey & Sons Inc., 2012, 456-487.
  2. Wang Q, and Zhou DM*, “Development of New Technologies for Viral Receptor Discovery”, in “Receptors”, He SP. Ed.; Peking Univ Press, 2012, 120-135.
  3. Yang J, Zhou DM and Wong-Staal F, “Screening of Small-Molecule compounds as Inhibitors of HCV Entry” in “Methods in Molecular Medicine, Hepatitis C Protocols”, Tang, H. Ed.; Human Press: 2009, 510: 295-304.
  4. M. Warashina, Zhou DM, T. Kuwabara & K. Taira , "Comprehensive Natural Products Chemistry", Söll, D.; Nishimura, S. Eds.; Elsevier Science, 235-278 (2003).

Patents

  1. Zhou D, Wang W, “Tumor-specific t cell based on non-natural sugar metabolic engineering and its construction method”, Faming Zhuanli Shenqing (2018), CN 108265027 A 20180710
  2. Zhou D, Wang Y, Liu S, Xu H, Wang W, Wu Y, Si L, Chen Y, Zhou X, “Method for constructing stable cell line carrying orthogonal tRNA/aminoacyl tRNA synthetase”, Faming Zhuanli Shenqing (2017), CN 109295100 A 20190201
  3. Zhou D, Si L, Zhang Z, Han X, Meng K, Zhang B, Xiao S, Zhang L, Zhou X, “Triterpenoid derivative, preparation and application in inhibiting Ebola virus”, Faming Zhuanli Shenqing (2017), CN 107304221 A 20171031
  4. Zhou D, Xia Q, Xu H, Zhang Z, Si L, Wu Y, Wang T, Zhang L, “System for efficient multipoint insertion of non-natural amino acid to mammalian cells”, Faming Zhuanli Shenqing (2017), CN 107022568 A 20170808
  5. Zhou D, Xia Q, Xu H, Zhang B, Si L, Yang Q, Yao T, Zhang L, “Construction of stable cell line carrying orthogonal tRNA/aminoacyl tRNA synthetase”, Faming Zhuanli Shenqing (2017), CN 107012121 A 20170804
  6. Zhou D, Si L, Zhou X, Zhang Z, Xu H, Tian Z, Yao T, Xiao S, Zhang C, Xia Q, Zhang L, “Preparation and application of site-directed mutant influenza virus and live vaccine”, Faming Zhuanli Shenqing (2017), CN 106929482 A 20170707
  7. Zhou D, Si L, Zhou X, Zhang Z, Xu H, Tian Z, Zhang C, Xiao S, Xia Q, Zhang L, “Preparation and application of mutant viruses”, PCT Int. Appl. (2017), WO 2017113786 A1 20170706.
  8. Zhou D, Yang Z, Wu Y, Zhang B, Zhu H, Xu H, Liu F, “Preparation of anti-Lys-azido antibody and conjugates with drug or radioisotope for imaging, tracing and immunotherapy of disease such as cancer”, Faming Zhuanli Shenqing (2016), CN 106146663 A 20161123.
  9. Zhou D, Zhang B, Chen J, Yu F, Zhang C, Si L, Wu L, “Method for preparing modified pegylated recombinant human interferon α2b for use in antiviral, antitumor and immunomodulating therapy”, PCT Int. Appl. (2015), WO 2015081858 A1 20150611.
  10. Zhou D, Wu L, Zhang B, Chen J, Yu F, Zhang C, Si L, Wu L,“Method for preparing modified pegylated recombinant human interferon α2b for use in antiviral, antitumor and immunomodulating therapy”, Faming Zhuanli Shenqing (2015), CN 104693300 A 20150610.
  11. Zhou D, Zhang C, Xiao S, Yao T, Zheng Y, Yu F, Si L, Zhang L, “Adeno-associated virus with site-directed mutagenesis and site-directed modification, and preparation method and application therefor”, PCT Int. Appl. (2015), WO 2015062516 A1 20150507
  12. Zhou D, Zhang C, Xiao S, Yao T, Zheng Y, Yu F, Si L, Zhang L, “Adeno-associated virus with site-directed mutagenesis and site-directed modification, and preparation method and application therefor”, Faming Zhuanli Shenqing (2015), CN 104592364 A 20150506.
  13. Zhou D, Chen J, Zhang B, Yu F, Zhang C, Si L, “Expression of nonnatural amino acid-labeled site-directed mutated and modified human interferon α2b”, Faming Zhuanli Shenqing (2014), CN 104099360 A 20141015.
  14. Zhou D, Yu M, Xiao S, Yu F, Peng Y, Qiu Y, Zhang L, “Preparation of triterpene derivatives as anti-influenza agents”, Faming Zhuanli Shenqing (2014), CN 103768078 A 20140507.
  15. Zhou D, Yu M, Xiao S, Yu F, Peng Y, Qiu Y, Zhang L, “Preparation of triterpene derivatives as anti-influenza agents”, PCT Int. Appl. (2014), WO 2014063441 A1 20140501
  16. Zhou D, Xiao S, Si L, Yu F, Shi Y, Wang H, Zhang L, “Preparation of triterpenoid-cyclodextrin covalent compounds for prevention or treatment of influenza or hepatitis C”, Faming Zhuanli Shenqing (2014), CN 103694375 A 20140402.
  17. Zhou D, Xiao S, Zhang Z, Yu F, Wang H, Wang Q, Peng Y, Zhang L, “Triterpene derivatives, their preparation method and use” Faming Zhuanli Shenqing (2013), CN 103127135 A 20130605.
  18. Zhou D, Zhang C, Xiao S, Zhang Y, Yu F, Zhao C, Chen J, Zhang L, “Preparation of growth hormones modified by site-directed mutagenesis for treatment of pituitary insufficiency caused dwarfism or Turner disease”, Faming Zhuanli Shenqing (2012), CN 102838671 A 20121226.
  19. Zhou D, Zhang Y, Zhao C, Zhang C, Yu F, Xiao S, Zhang L, “Preparation of orientedly mutated and orientedly modified vesicular stomatitis virus envelope protein”, Faming Zhuanli Shenqing (2012), CN 102838663 A 20121226.
  20. Zhou D, Gao X, Xiong W, Zhao J, Zhang L, “Sensitizer for reversing or lowering resistance to radiotherapy of esophageal carcinoma, its screening technique and application”, Faming Zhuanli Shenqing (2012), CN 102836433 A 20121226.
  21. Zhou D, Gao X, Xiong W, Zhao J, Zhang L, “Sensitizer for reversing or lowering resistance to radiotherapy of esophageal carcinoma, its screening technique and application”, PCT Int. Appl. (2012), WO 2012175052 A1 20121227
  22. Zhou D, Wang H, Ye M, Xiao S, Sun D, Zhang L, “Preparation of Echinocystic acid derivatives for treating hepatitis C assocd. viral diseases”, Faming Zhuanli Shenqing (2012), CN 102584930 A 20120718.
  23. Zhou D, Chatterton JE, Ke N, Zhang J, Li H and Wong-Staal F. Inducible siRNA expression cassette and method use, International Patent, WO 2006/078880.
  24. Zhou D, Wang C, Zhang J, Li H and Wong-Staal F, Methods for making hairpin siRNA libraries, International Patent, 2006, 016556-004700.
  25. Zhou D, Zhang J, Wang C, Yang JP and Wong-Staal F, Methods for inhibiting entry of Hepatitis C virus into cells, International patent, 2007, P-IMM1025.

 

点击次数：16545  更新时间：2013-12-30 08:36:57  【打印此页】  【关闭】
上一条：返回列表  下一条：返回列表