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NMR系列讲座(4月6日起,共8次)

发布日期:2012-04-06 14:26:16点击:

        

   NMR 系列讲座

  (共8次)

     时间:四月六日起,每周一、五下午2:00开始,每次大约2小时。共8次。

  地点:国重2号楼2层报告厅

 

  Lecturer: Dr. Vasudevan Ramesh

                    School of Chemistry the University of Manchester

  Learning objectives

  Understanding the NMR experimental parameters which govern the quality of resultant NMR spectra

  To elaborate on the principles and experimental methods involved in the acquisition, data processing and interpretation of one- and two-dimensional NMR spectra

  To demonstrate the application of NMR in elucidating structures with suitable examples

  Syllabus

  Basic principles of NMR and experimental parameters,

  1H, 13C chemical shifts; multinuclear NMR

  Relationship between the NMR spectrum and molecular structure

  Spin–spin coupling; H-H, C-H coupling constants; Karplus relationship

  Analysis of NMR spectra; nomenclature of spin systems

  Fourier transformation; sensitivity enhancement; nuclear relaxation

  Multipulse NMR techniques; DEPT experiment

  Two-dimensional NMR; chemical shift correlation (COSY, TOCSY, HMQC and HMBC)

  The Nuclear Overhauser Effect; 1D NOE , 2D NOESY and ROESY

  NMR Applications; dynamic NMR

  Intended learning outcomes

  Demonstrate an understanding of the NMR phenomenon and its applications

  Explain the significance of chemical shifts (1H,13C) and their use in functional group identification

  Describe the physical basis of spin-spin coupling

  Exemplify how coupling constants can be used to determine stereochemical relationships

  Show how enhancement of sensitivity takes place due to Fourier transformation

  Explain the utility of multipulse NMR in spectral simplification

  Describe in a simple way how 2D NMR works and the different types of experiments that can be performed

  Rationalise the NOE effect ( 1D and 2D ) to solve organic structural problems

  Demonstrate how NMR can be applied to investigate dynamic effects ( e.g. barriers to rotation etc)

 

  Dr. Vasudevan Ramesh是重点室的客座教授,多年从事NMR工作,经验丰富。这次系列讲座内容广泛,包括NMR的基础知识和高级应用。欢迎对核磁共振波谱感兴趣的老师、同学参加。还有继续教育学分!

 

  天然药物和仿生药物国家重点实验室

  2012.04.06