科学研究队伍

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杨秀伟 教授

研究领域: 天然产物生物转化
电话: +86-10-82805106
联系邮箱: xwyang@bjmu.edu.cn

个人简历

男,1958 年出生。北京大学教授、博士生导师。长期致力于中药ADMET/Act.的研究。国家十二五科技支撑计划“基于生物、化学、信息等多学科技术集成的中药现代化发展关键技术研究2012BAI29B02”项目首席科学家。主要社会兼职:国家药典委员会委员,世界中医药学会联合会中药化学专业委员会副会长,世界中医药学会联合会中药分析专业委员会常务理事,中华中医药学会理事等;J. Asian Nat. Prod. Res.、《中国中药杂志》、《药物分析杂志》等16 刊杂志编委。

主要研究领域

主要研究领域包括天然药物化学、天然药物化学成分及其生物转化与创新药物发现、中药复杂体系科学问题研究和药物的ADMET/Act.研究平台建设。

代表性论文

1. Ma Li-Yuan, Zhang You-Bo, Zhou Qi-Le, Yang Yan-Fang, Yang Xiu-Wei*. Simultaneous determination of eight ginsenosides in rat plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: Application to their pharmacokinetics. Molecules, 2015, 20(12):21597–21608. 2014-IF 2.416

2. Ma Li-Yuan, Zhou Qi-Le, Yang Xiu-Wei*. New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng. Bioorganic & Medicinal Chemistry Letters, 2015, 25(22):5321–5325. 2014-IF 2.42

3. Wu Shuai, Xu Wei, Wang Fu-Rong, Yang Xiu-Wei*. Study of the biotransformation of Tongmai Formula by human intestinal flora and its intestinal permeability across the Caco-2 cell monolayer. Molecules, 2015, 20(10):18704-18716.  2014-IF 2.416

4. Ma Li-Yuan, Yang Xiu-Wei*. Six new dammarane-type triterpenes from acidic hydrolysate of the stems-leaves of Panax ginseng and their inhibitory–activities against three human cancer cell lines. Phytochemistry Letters, 2015, 13:406-412.  2014-IF 1.45

5. Wei Wei, Rena Kasimu, Yang Xiu-Wei*. New salicin derivatives from the leaves of Populus euphratica. Journal of Asian Natural Products Research, 2015, 17(5):491-496. 2014-IF 0.913

6. Zhou Qi-Le, Yang Xiu-Wei*. Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells. Bioorganic & Medicinal Chemistry Letters, 2015, 25:3112–3116. 2014-IF 2.42

7. Yang Yan-Fang, Xu Wei, Song Wei, Ye Min, Yang Xiu-Wei*. Transport of twelve coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR cell monolayer—An in vitro model for blood-brain barrier permeability. Molecules, 2015, 20(7):11719-11732   2014-IF 2.416

8. Li Fei, Yang Xiu-Wei*, Krausz Kristopher, Nichols Robert, Xu Wei, Patterson Andrew, Gonzalez Frank J.*. Modulation of colon cancer by nutmeg. Journal of Proteome Research (J. Proteome Res.), 2015, 14 (4):1937-1946.  2014-IF 4.245

9. Deng Gai-Gai, Wei Wei, Yang Xiu-Wei*, ZhangYou-Bo, Xu Wei, Gong Ning-Bo, Lü Yang, Wang Feng-Feng. New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells. Fitoterapia, 2015, 101:194-200.  2014-IF 2.345

10. Cao Gui-Yun, Xu Wei, Yang Xiu-Wei*, Gonzalez FJ, Li Fei. New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. Food Chemistry, 2015, 173:231–237. 2014-IF 3.391

11. 杨秀伟,李珂珂,周琪乐. 人参茎叶中1个新皂苷20(S)-人参皂苷Rf2. 中草药,2015, 46(21): 3137-3145.

12. 李珂珂, 杨秀伟*. 人参茎叶中1个新三萜类天然产物. 中草药, 2015, 46(2):169-173.

13. 邓改改,崔治家,杨秀伟*. 川白芷根极性化学成分研究. 中国中药杂志,2015, 40(19):3805-3810.

14. 邓改改,杨秀伟*,张友波,徐嵬,韦玮,陈天丽. 川白芷根脂溶性化学成分研究[J]. 中国中药杂志,2015, 40(11):2148-2156.

15. 马丽媛,杨秀伟*. 人参茎叶总皂苷酸水解产物化学成分研究. 中草药, 2015, 46(17):2522-2533.

16. Ma Zhao-Tang, Yang Xiu-Wei*, Zhang Ying, Liu Jian-Xun. Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of Huang-Lian-Jie-Du-Tang decoction. Journal of Asian Natural Products Research, 2014, 16(5):483-496. 2014-IF 0.968

17. Qian Ping, Yang Xiu-Wei*. New limonoids from Coptidis Rhizoma-Euodiae Fructus couple. Journal of Asian Natural Products Research, 2014, 16(4):333-344. 2014-IF 0.968

18. Li Ying, Yang Xiu-Wei*. New eudesmane-type sesquiterpenoids from the processed rhizomes of Atractylodes macrocephala. Journal of Asian Natural Products Research, 2014, 16(2):123-128.  2014-IF 0.968

19. Yao Chun-Mei, Yang Xiu-Wei*. Bioactivity-guided isolation of polyacetylenes with inhibitory activity against NO production in LPS-activated RAW264.7 macrophages from the rhizomes of Atractylodes macrocephala. Journal of Ethnopharmacology, 2014, 151(2):791–799.  2014-IF 2.939

20. Chen Tian-Li, Zhang You-Bo, Xu Wei, Kang Ting-Guo, Yang Xiu-Wei*. Biotransformation of isoimperatorin by rat liver microsomes and its quantification by LC–MS/MS method. Fitoterapia, 2014, 93:88-97.  2014-IF 2.216

21. Qian Ping, Yang Xiu-Wei*. Five new alkaloids from Coptidis Rhizoma–Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells. Fitoterapia, 2014, 93:74-80.  2014-IF 2.216

22. Wu Ni, Xu Wei, Zhang You-Bo, Yang Xiu-Wei*. Biotransformation of malabaricone C by rat hepatic microsomes and cytotoxic activities against gastric cancer cells in vitro. Journal of Chinese Pharmaceutical Sciences, 2014, 23(4):241-245.

23. Cao Gui-Yun, Yang Xiu-Wei*. Biotransformation of methyleugenol by rat hepatic microsomes. Journal of Chinese Pharmaceutical Sciences, 2014, 23(5):311-316.

24. 钱平,杨秀伟*. 左金方的生物碱类成分及其对肿瘤细胞的细胞毒活性. 中草药, 2014, 25(1):8-15.

25. 赵爱红,杨秀伟*. 兴安白芷脂溶性部位中新的天然产物. 中草药, 2014, 45(13):1820-1828.

26. 杨雁芳,吴妮,杨秀伟*. 用于中药复方物质基础研究的Caco-2细胞胶原包被6孔转运板体系的构建. 中国中药杂志,2014, 39(3):515519.

27. Yang Xin-Bao, Qian Ping, Yang Xiu-Wei*, Liu Jian-Xun*, Gong Ning-Bo, Lv Yang. Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages. Journal of Asian Natural Products Research, 2013, 15(10):1130-1138.  2013-IF 0.948

28.. Wu Xiu-Wen, Wang Ru-feng, Yuan Ming, Xu Wei, Yang Xiu-Wei. Dulbecco's modified Eagle's medium and minimum essential medium – Which one is more preferred for establishment of Caco-2 cell monolayer model used in evaluation of drug absorption?. Pharmazie, 2013, 68:805–810. 2013-IF 0.962

29. Gao Xin, Yang Xiu-Wei*, Marriott PJ. Evaluation of Coptidis Rhizoma–Euodiae Fructus couple and Zuojin products based on HPLC fingerprint chromatogram and simultaneous determination of main bioactive constituents. Pharmaceutical Biology, 2013, 51(11):1384–1392. 2013-IF 1.206

30. Zhou Qi-Le, Wang Ying-Feng, Yang Dong-Hui*, Xu Feng, Zhao Xin, Zhang Lei, Liang Jing, Yang Xiu-Wei*. Identification of the absorptive constituents and their metabolites in vivo of Puerariae Lobatae Radix decoction orally administered in WZS-miniature pigs by HPLC-ESI-Q-TOFMS. Biomedical Chromatography, 2013, 27(9):1208-1218. 2013-IF 1.945 

31. Cao Gui-Yun, Yang Xiu-Wei*, Xu Wei, Li Fei. New inhibitor of nitric oxide production from the seeds of Myristica fragrans. Food and Chemical Toxicology, 2013, 62:167–171. 2013-IF 3.01

 

科研项目