科学研究队伍

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蔡少青 教授

研究领域: 中药的品种整理和质量研究;生药的化学成分及药理活性
电话: +86-10-82801693
联系邮箱: sqcai@bjmu.edu.cn

个人简历

国家杰出青年基金获得者、人事部“中青年有突出贡献专家”、跨世纪优秀人才

  

男,1960 年出生,北京大学教授,博士生导师。长期致力于生药质量评价、中药药效物质及作用机理等的研究。承担国家七五~十五攻关项目,国家自然科学基金重点、杰出青年项目,国家“973”项目,国家十一五科技支撑项目等 30 余项科研课题。建立了中药细辛等10 余种药材质量标准,被国家药典采纳。提出中药“多成分同靶点叠加作用”和“毒性分散效应”新理论,设计了“超低毒性多重药物”研发思路。获国家科技进步二等奖1 项。曾兼任何梁何利科技基金委评审专家、中国药学会理事兼中药和天然药物专业委员会副主任委员,现兼任世界中医药学会联合会药用植物资源利用专委会副会长、国家科技奖评审专家、国家药典会委员。在 J. Nat. Prod.Chromatography APhytochemistryPlanta MedicaTalanta 等重要学术刊物上发表论文 260 篇,授权专利 9 项。主编参编著作 13 部,其中连任人民卫生出版社《生药学》第 4~7 版(2003~2016 年)教材主编。任《中国中药杂志》、《中国天然药物》、 J. Nat. Med. Pharm. Crops 等编委。

主要研究领域

1.生药品种鉴别和质量评价

2.生药化学成分及活性研究 

3.生药体内过程研究

代表性论文

1. A systematic study on the influencing parameters and improvement of quantitative analysis of multi-component with single marker method using notoginseng as research subject. Talanta. Chao-Qun Wang, Xiu-Hong Jia, Shu Zhu, Katsuko Komatsu, Xuan Wang*, Shao-Qing Cai. 2015, 134: 587-595.

2. Aristolochic acid nephropathy: variation in presentation and prognosis. Nephrology Dialysis Transplantation. Li Yang, Tao Su, Xiao-Mei Li, Xuan Wang, Shao-Qing Cai, Li-Qiang Meng, Wan-Zhong Zou, Hai-Yan Wang       2012,27(1): 292-298.

3. Aristololactams and aporphines from the stems of Fissistigma oldhamii (Annonaceae). Phytochemistry. Yue-Wei Ge, Shu Zhu, Ming-Ying Shang, Xin-Yu Zang, Xuan Wang, Yan-Jing Bai, Li Li, Katsuko Komatsu*, Shao-Qing Cai*. 2013, 86: 201-207.

4. Comparative analysis of two species of Asari Radix et Rhizoma by electronic nose, headspace GC-MS and chemometrics. Journal of Pharmaceutical and Biomedical Analysis. Chen Li, Feng Xu, Chen Cao, Ming-Ying Shang, Cui-Ying Zhang, Jie Yu, Guang-Xue Liu, Xuan Wang, Shao-Qing Cai*. 2013, 85: 231-238.

5. A-Type Proanthocyanidins from the stems of Ephedra sinica (Ephedraceae) and their antimicrobial activities. Molecules. Xin-Yu Zang, Ming-Ying Shang*, Feng Xu, Jing Liang, Xuan Wang, Masayuki Mikage, Shao-Qing Cai*. 2013, 18: 5172-5185.

6. Chemical constituents from the rhizomes of Smilax glabra and their antimicrobial activity. Molecules. Shuo Xu, Ming-Ying Shang*, Guang-Xue Liu, Feng Xu, Xuan Wang, Cheng-Chao Shou, Shao-Qing Cai*. 2013, 18: 5265-5287.

7. Alkyl and phenolic glycosides from Saussurea stella. Fitoterapia. Tian-Min Wang, Ru-Feng Wang, Hu-Biao Chen*, Ming-Ying Shang*, Shao-Qing Cai. 2013, 88: 38-43.

8. Chemical profile analysis and comparison of two versions of the classic TCM formula Danggui Buxue Tang by HPLC-DAD-ESI-IT-TOF-MSn. Molecules. Ya-Zhou ZHANG, Feng XU, Tao YI, Jian-Ye ZHANG, Jun XU, Yi-Na TANG, Xi-Chen HE, Jing LIU, Hu-Biao CHEN*. 2014, 19(5): 5650-5673.

9. Application of microscopy for discrimination of eight Swertia Species utilized in the traditional Chinese medicine‘Qingyedan’. Microscopy Research and Technique. Yao-Li Li, Ming-Ying Shang, Ji-Jun Chen, Shao-Qing Cai. 2013, 76(3): 296-310.

10. Binary chromatographic fingerprint analysis of Stemonae Radix from three Stemona plants and its applications. Journal of Natural Medicines. Lan-Lan FAN, Feng XU, Jun-Ping HU, Dong-Hui YANG, Hu-Biao CHEN, Katsuko KOMATSU, Shu ZHU, Ming-Ying SHANG, Xuan WANG, Shao-Qing CAI*. 2015, 69(3): 402-410.

11. Comparison of contents of five ephedrine alkaloids in three official origins of Ephedra Herb in China by high-performance liquid chromatography. Journal of Natural Medicines. Hao HONG, Hu-Biao CHEN, Dong-Hui YANG, Ming-Ying SHANG, Xuan WANG, Shao-Qing CAI*, Masayuki MIKAGE. 2011,65(3-4):623-628.

12. 5–Methoxyaristololactam I, the first natural 5–substituted aristololactam from Asarum ichangense. Natural Product Communications. Bai-Bo XIE, Ming-Ying SHANG*, Kuo-Hsiung LEE*, Xuan WANG, Katsuko KOMATSU, Shao-Qing CAI. 2011,6(1):11-14.

13. 单叶细辛中一个新的马兜铃酸类化合物. 药学学报. 谢百波,尚明英*,王璇,蔡少青*Kuo-hsiung LEE. 2011,46(2):188-192

14. 高效液相色谱法测定土茯苓药材中7种活性成分的含量. 中国中药杂志. 徐硕, 尚明英*, 刘广学, 徐风, 李逢春, 王璇, 蔡少青*. 2015, 40(3): 469-479.

15. 辽细辛中十二碳四烯酰胺AB的定性及定量分析研究. 中国中药杂志. 谢德媚, 刘广学, 徐风, 尚明英, 张子为, 王璇, 蔡少青*. 2015, 40(4): 691-699.

16. 中药三七“一测多评”质量控制方法的系统研究. 中国中药杂志. 王超群,贾秀虹,陈季,肖新月,王璇*,蔡少青*. 2012,3722):3438-3445.

17. 黄芩不同规格与化学成分及内在质量相关性的研究. 中国中药杂志. 王丹,蒋亚杰,梁艳,赵琳,蔡少青,尚明英,袁鹏飞,赵玉英,王璇*. 2012,374):426-433.

18. 地龙的HPLC特征图谱研究. 中国药房. 黄帅, 徐风, 杨平, 杨雪雁, 刘广学, 尚明英, 王璇, 蔡少青*. 2015, 26(21): 2971-2974.

19. Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy British Journal of Pharmacology. LQ Meng, JW Tang, Y Wang, JR Zhao, MY Shang, M Zhang,SY Liu, L Qu, SQ Cai and XM Li. 2011,162:1805-1818.

20. Development of a novel mitochondria-based centrifugal ultrafiltration/liquid chromatography/mass spectrometry method for screening mitochondria-targeted bioactive constituents from complex matrixes: herbal medicines as a case study. Journal of Chromatography A      Xing-Xin YANG, Feng XU, Dan WANG, Zhi-Wei YANG, Huan-Ran TAN, Ming-Ying SHANG, Xuan WANG*, Shao-Qing CAI*. 2015, 1413: 33-46.

21. Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb. Toxicology Letters. Yujing Gao, Yahui Su, Like Qu, Shuo Xu, Lin Meng, Shao-Qing Cai, Chengchao Shou. 2011,207: 112-120.

22. Exploring in vitro, in vivo metabolism of mogroside V and distribution of its metabolites in rats by HPLC-ESI-IT-TOF-MSn     Journal of Pharmaceutical and Biomedical Analysis. Feng XU, Dian-Peng LI*, Zhen-Cong HUANG, Feng-Lai LU, Lei WANG, Yong-Lin HUANG, Ru-Feng WANG, Guang-Xue LIU, Ming-Ying SHANG, Shao-Qing CAI*. 2015, 11: 418-430.

23. Profiling and identification of the metabolites of calycosin in rat hepatic 9000×g supernatant incubation system and the metabolites of calycosin-7-O-b-D-glucoside in rat urine by HPLC-DAD-ESI-IT-TOF-MSn technique       Journal of Pharmaceutical and Biomedical Analysis. Ya-Zhou Zhang#, Feng Xu#, Jing Dong, Jing Liang, Yuki Hashi, Ming-Ying Shang, Dong-Hui Yang, Xuan Wang, Shao-Qing Cai*. 2012, 70: 425-439.

24. The profiling and identification of the absorbed constituents and metabolites of Paeoniae Radix Rubra decoction in rat plasma and urine by the HPLC-DAD-ESI-IT-TOF-MSn technique: A novel strategy for systematic screening and identification of absorbed constituents and metabolites from traditional Chinese medicines      Journal of Pharmaceutical and Biomedical Analysis. Jing Liang#, Feng Xu#, Ya-Zhou Zhang, Shuai Huang, Xin-Yu Zang, Xin Zhao, Lei Zhang, Ming-Ying Shang, Dong-Hui Yang, Xuan Wang, Shao-Qing Cai*. 2013, 83: 108-121.

25. Identification of absorbed constituents in the rabbit plasma and cerebrospinal fluid after intranasal administration of Asari Radix et Rhizoma by HS-SPME-GC-MS and HPLC-APCI-IT-TOF-MSn. Molecules. Chen LI#, Feng XU#, De-Mei XIE, Yu JING, Ming-Ying SHANG, Guang-Xue LIU, Xuan WANG, Shao-Qing CAI*. 2014, 19(4): 4857-4879.

26. The in vivo absorbed constituents and metabolites of Danshen decoction in rats identified by HPLC with electrospray ionization tandem ion trap and time-of-flight mass spectrometry. Biomedical Chromatography Xin ZHAO, Dong-Hui YANG*, Feng XU, Shuai HUANG, Lei ZHANG, Guang-Xue LIU, Shao-Qing CAI*. 2015, 29(2): 285-304.

27. The profiling and identification of the metabolites of (+)-catechin and study on their distribution in rats by HPLC-DAD-ESI-IT-TOF-MSn technique. Biomedical Chromatography. Jing LIANG#, Feng XU#, Ya-Zhou ZHANG, Xin-Yu ZANG, Dan WANG, Ming-Ying SHANG, Xuan WANG, De-Hua CHUI, Shao-Qing CAI*. 2014, 28(3): 401-411.

28. Absorptive constituents and their metabolites in drug-containing urine sample of WZS-miniature pig orally administrated with Buyang Huanwu Decoction. Journal of Natural Medicines. Dong-Hui YANG, Xiang-Liang REN, Feng XU, Xiao-Qing MA, Guang-Xue LIU, Cang-Hai LI, Chen LI, Shao-Qing CAI*. 2014, 68(1): 11-21. 

29. Effects of CS-1 on A431 cell proliferation, cell cycle, and epidermal growth factor receptor signal transduction. Acta Biochimica et Biophysica Sinica. Hai-Yan Du, Bo Xu, Cai-Xia Wu, Min Li, Fu-Xiang Ran, Shao-Qing Cai, Jing-Rong Cui*. 2012, 44: 136-146.

科研项目