科学研究队伍

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刘俊义 教授

研究领域: 单碳转移酶的催化机理及抑制剂研究,新型非核苷
电话: +86-10-82801706
联系邮箱: jyliu@bjmu.edu.cn

个人简历

男,1952 年出生。北京大学教授,博士生导师,1975 年本科毕业于北京医科大学药学院,留校任教;1994 年获英国Newcastle-Cambridge 大学理学博士学位;1994-1997 年在英国Newcastle 做博士后研究工作,从事抗病毒和抗肿瘤药物的研究;1997 年回北京大学药学院化学生物学系工作。现任教授、博士生导师,曾任药学院院长、北京大学创新药物研究院常务副院长。兼任教育部高等学校药学类教执委副主任委员,国务院学位委员会学科评议组药学组成员,教育部药品类高职高专教执委副主任委员,全国高等药学研究会副理事长,北京药学会常务理事,北京药师协会副会长,中国医药教育协会副会长,《中国药学(英文版)》副主编,《药物化学》、《中国药学年鉴》编委,国家科学技术奖评审专家,首都医科大学、新疆石河子大学、海南医学院客座教授。研究领域包括单碳转移酶催化机理研究,蛋氨酸合酶抑制剂的设计、合成与生物活性研究,抗HIV 药物的设计、合成与构效关系研究,中枢神经保护剂的设计、合成与生物活性研究。

主要研究领域

1.单碳转移酶的催化机理及抑制剂研究 

2.新型非核苷

代表性论文

(1) Neuroprotective effects of (E)-3,4-diacetoxystyryl sulfone and sulfoxide derivatives in vitro models of Parkinson's disease. Xianling Ning, Mengmeng Yuan, Ying Guo, Chao Tian, Xiaowei Wang, Zhili Zhang, Junyi Liu*. J. Enzyme Inhib. Med. Chem., 2015, 15, 1-6. (2.3)

(2) An approach to synthesis of pyrimido[b]azepines via Ruthenium-catalyzed ring-closing metathesis. TongBo Zhang, YuanYuan Cao, ShaoTong Wu, Yu Zhang, Ying Guo, JianXiong Zhao, XueFeng Sun, QuanZhi Yang, ZhiLi Zhang, Chao Tian, JunYi Liu*, XiaoWei Wang.* Synthesis, 2015, 47,3292-3300. (2.5)

(3) The HEPT analogue, 1-((benzyloxy) methyl)-6-(3, 5-dimethylbenzyl)-5- iodopyrimidine-2, 4(1H, 3H)-dione (WPR-6), is active against a broad spectrum of HIV-1 strains of different subtypes with drug-resistance. Antimicrobial Agents and Chemotherapy. 2015, 59:8, 4882-4888. (4.6)

(4) Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs. Yuanyuan Cao, Yu Zhang, Shaotong Wu, Quanzhi Yang, Xuefeng Sun, Jianxiong Zhao, Fen Pei, Ying Guo, Chao Tian, Zhili Zhang, Haining Wang, Liying Ma, Junyi Liu,* Xiaowei Wang.* Bioorg. Med. Chem. 2015, 23, 149–159. (2.9)

(5) 5-Iodo-2-arylalkylthio-6-aryl pyrimidin-4(3H)-ones as non-nucleoside anti-HBV agents. Yu Zhang, Xuefeng Sun, Ningning Fan, Jianxiong Zhao, Jing Tu, Xiangmei Chen, Junyi Liu* and Xiaowei Wang*. Med. Chem. Commun., 2015, 6, 1438–1443. (2.7)

(6) Synthesis, antifolate and anticancer activities of N5-substituted 8,10-dideazatetrahydrofolate analogues. Chao Tian, zhili Zhang, Meng Wang, Mengmeng Yuan, Xiaowei Wang, Junyi Liu. Chem. Bio. Drug Design, 2015,doi: 10.1111/cbdd.12681. accepted. (2.5)

(7) Stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(2H)-ones as potency inhibitors of HIV-1 variants. Shaotong Wu, Qianqian Yin, Liang Zhao, Ningning Fan, Xiaowan Tang Jianxiong Zhao, Tao Sheng, Ying Guo, Chao Tian, Zhili Zhang, Weisi Xu, Zhenming Liu, Shibo Jiang,d Liying Ma,* Junyi Liu*, and Xiaowei Wang*. Org. Biomolecular Chem . 2015, DOI: 10.1039/c5ob02154e (3.56)

(8) Development and validation of a high performance liquid chromatography method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor and its application to a pharmacokinetic study in rats. YingYuan Lu, Xin Wang, XiaoWeiWang, JunYi Liu, Pu Li, Hong Ren, YaQing Lou, Chuang Lu, GuoLiang Zhang.  Biomed. Chromatogr., 2015DOI 10.1002/bmc.3457, (1.7)

(9) N5-甲基四氢叶酸类似物的合成及其蛋氨酸合成酶抑制活性研究,杜义青,袁蒙蒙,王锰,刘俊义,张志丽。中国药物化学, 2015, 25(6), 415-423

(10Design, synthesis, and biological evaluation of (E)3,4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents. Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Shi Xueqi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma, Zhili Zhang,* Junyi Liu*, J. Med. Chem., 2014, 57(10), 4302-4312. (5.6)

(11) Synthesis and biological evaluation of novel 2-arylalkylthio-5-iodine-6-substituted-benzyl- pyrimidine-4(3H)-ones as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Liang Zhang, Xiaowan Tang, Yuanyuan Cao, Shaotong Wu, Yu Zhang, Jianxiong Zhao, Ying Guo, Chao Tian, Zhili Zhang, Junyi Liu, Xiaowei Wang* Molecules, 2014, 19(6), 7104-7121. (2.4)

(12) 谢欣,王孝伟*,刘俊义*。免疫途径抗HIV信号通路: cGAS-STING研究进展。国际药学研究杂志,201410月,41卷,第5期,525页。

(13) Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTIResistant HIV1 strains, Amin Li, Yabo Ouyang, Ziyun Wang, Yuanyuan Cao, Xiangyi Liu, Li Ran, Chao Li, Li Li, Liang Zhang, Kang Qiao, Weisi Xu, Yang Huang, Zhili Zhang, Chao Tian, Zhenming Liu, Shibo Jiang, Yiming Shao, Yansheng Du, Liying Ma,* Xiaowei Wang,* Junyi Liu,* J. Med. Chem. 2013, 56, 3593-3608. (5.6)

(14) Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injury. Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Zhili Zhang, Xiaowei Wang, Zhizhong Ma, Junyi Liu. Bioorg. Med. Chem. 2013, 21, (17), 5589–5597. (2.9)

(15) Rapid Access to 10-(Cyclohexylimino)-7,9-diazaspiro[4.5]decane-6,8-dione Derivatives for HIV-1 Reverse Transcriptase Inhibition via Ruthenium-Catalyzed Ring-Closing Metathesis. Tongbo Zhang, Shaotong Wu, Yuanyuan Cao, Yuhong Fu, Ying Guo, Liang Zhang, Li Li, Han Zhou, Xiangyi Liu, Chao Li, Xiaowan Tang, Zhili Zhang, Chao Tian, Xiaowei Wang,* Junyi Liu*. Synthesis, 2013, 45, 2273-2279. (2.5)

(16)  Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation. Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Xiaowei Wang, Zhizhong Ma, Zhili Zhang,* Junyi Liua,* Bioorg. Med. Chem. Lett. 2013, 23, (13), 3700–3703. (2.3)

(17) New efficient and flexible synthetic route to Emivirine and its analogs. Li Li, Liying Ma, Xiaowei Wang,* Junyi Liu*, J. Heterocyclic. Chem. 2013, 50, 164. (1.2)

(18) Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate. Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang. Molecules, 2012, 17, 5604-5614. (1.99)

(19) Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo- 6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance. Xiaowei Wang, Jianfang Zhang, Yang Huang, Ruiping Wang, Liang Zhang, Kang Qiao, Li Li,Chang Liu, Yabo Ouyang, Weisi Xu, Zhili Zhang, Liangren Zhang, Yiming Shao, Shibo Jiang, Liying Ma, Junyi Liu. J. Med. Chem. 2012, 55, 2242−2250. (5.2)

(20) Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogues as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents. Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Bernard T. Golding, Roger J. Griff, Yansheng Du, Junyi Liu. Euro. J. Med. Chem. 2012, 58, 228-236. (3.2)

(21) Rapid access to multi-substituted pyrimido[4,5-b][1,4]diazepine-2,4,6-trione and pyrimido[4,5-b][1,4]diazepine-2,4-dione as novel and versatile scaffolds for drug discovery. Gong Li, Xiaowei Wang , Chao Tian, Tongbo Zhang, Zhili Zhang, Junyi Liu. Tetrahedron Letters, 2012, 53, 5193–5196. (2.4)

(22) 蛋氨酸合酶活性筛选体系的建立,郭莹,李超,张志丽,田超,王孝伟,刘俊义。药学学报,201247(11)1463-1460

(23) 具噻吩环8-去氮杂叶酸类似物的合成及生物活性研究,周受辛, , , 王孝伟,刘俊义, 张志丽,有机化学,2012321944-1950

(24) Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors. Yang Huang# , Xiaowei Wang#, Xiaoling Yu, Lin Yuan, Ying Guo, Weisi Xu, Tiejun Liu, Junyi Liu, Yiming Shao* and Liying Ma*. Virology Journal. 2011, 8: 230. (2.5)

(25) N-{4-{N-甲基-N-[2-羟基-3-(2,4-二氧代-1,2,3,4-四氢嘧啶-5-)氨基]丙基}氨基-3-}苯甲酰基-L-谷氨酸二乙酯及其衍生物的合成,邓喜玲,刘卫东,李超,张志丽,王孝伟,刘俊义。有机化学,2011311),75-81

(26) 4-氨基-N8,N10-二碳杂-N5-取代四氢叶酸类似物的合成及生物活性研究,田 超,李 ,张志丽,王孝伟,刘俊义。有机化学,201131111820-1827

科研项目