科学研究队伍

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时杰 研究员

研究领域: 药物成瘾及相关疾病的神经机制和干预策略研究
电话: 010-82801593
联系邮箱: shijie@bjmu.edu.cn

个人简历

国家杰出青年基金获得者 

 

女,研究员,博士生导师,国家杰出青年基金获得者,北京大学中国药物依赖性研究所常务副所长,药物依赖性研究北京市重点实验室主任,《中国药物依赖性杂志》主编,中国毒品滥用防治专家委员会副主任委员兼秘书长,中国毒理学会药物依赖性专业委员会副主任委员,中国毒理学会理事、中国心理学会生理心理学分会理事、中国药物滥用防治协会常务理事、中国神经科学学会精神病学基础与临床分会委员、中国睡眠研究会睡眠与心理卫生专业委员会常务委员,长期从事药物成瘾及相关疾病的神经机制和干预策略研究,在Science、JAMA Psychiatry、Am J Psychiatry、Biol Psychiatry、Neuropsychopharmacology、J NeurosciSCI期刊发表论文80余篇,多次获得教育部优秀成果自然科学奖一等奖、中华医学科技奖二等奖等学术奖励。作为负责人主持国家自然科学基金(杰出青年基金、联合基金重点项目等)、创新群体基金、科技部(973计划项目、科技支撑计划、重点研发计划、国家重大新药创制)、军科委国防科技创新课题等科研项目。

主要研究领域

药物成瘾及相关疾病的神经机制和干预策略研究

代表性论文

1. Chen J, Liang J, Lin X, Zhang Y, Zhang Y, Lin L, Shi J*. Sleep deprivation promotes habitual control over goal-directed control: behavioral and neuroimaging evidence. J Neurosci. 2017. 37(49):11979-11992

 

2. Li SX#, Han Y#, Xu LZ#, Yuan K, Zhang RX, Sun XY, Xu DF, Yuan M, Deng JH, Meng SQ, Gao XJ, Wen Q,Liu LJ, Zhu WL, Xue YX, Zhao M, Shi J, Lin Lu*. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry. 2017, 23(3):597-608. 

 

3. Liang J#, Li JL#, Han Y#, Luo YX, Xue YX, Zhang Y, Zhang Y, Zhang LB, Chen ML, Lu L, Shi J*. Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory. J Neurosci. 2017, 37(37):8938-8951

 

4. Hu D, Yu ZL, Zhang Y, Han Y, Zhang W, Lu L, Shi J*. Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress. Sci Rep. 2017, 7(1):11878

 

5. Sun Y#, Wang GB#, Lin QX#, Lu L, Shu N, Meng SQ, Wang J, Han HB, Yong H, Shi J*. Disrupted white matter structural connectivity in heroin abusers. Addict Biol. 2017, 22(1):184-195

 

6. Zhang Y#, Xue Y#, Meng S, Luo Y, Liang J, Li J, Ai S, Sun C, Shen H, Zhu W, Wu P, Lu L, Shi J*. Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse. Biol Psychiatry. 2016, 79(11): 928-39

 

7. Sun Y#, Yu H#, Chen J#, Liang J, Lu L, Zhou X*, Shi J*. Neural substrates and behavioral profiles of romantic jealousy and its temporal dynamics. Sci Rep. 2016, 6:27469

 

8. Sun Y, Zhao LY, Wang GB, Yue WH, He Y, Shu N, Lin QX, Wang F, Li JL, Chen N, Kosten TR, Feng JJ, Tan YL, Han HB, Lu L, Shi J*. ZNF804A variants confer risk for heroin addiction by modulating neurocognitive and neuroanatomical phenotypes. Addict Biol. 2016, 21(3): 657-66

 

9. Xue YX#, Deng JH#, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L*. Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving. JAMA Psychiatry. 2017,74(3):224-232

 

10. Jian M#, Luo YX#, Xue YX, Han Y, Shi HS, Liu JF, Yan W, Wu P, Meng SQ, Deng JH, Shen HW, Shi J*, Lu L*. eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. J Neurosci. 2014, 34(30):10010-10021

 

11. Suo L#, Zhao L#, Si J, Liu J, Zhu W, Chai B, Zhang Y, Feng J, Ding Z, Luo Y, Shi H, Shi J*, Lu L*. Predictable chronic mild stress in adolescence increases resilience in adulthood. Neuropsychopharmacology. 2013, 38(8):1387-400

 

12. Sun LL#, Zhang Y#, Liu JF, Wang J, Zhu WL, Zhao LY, Xue YX, Lu L, Shi J*. Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine. Int J Neuropsychopharmacol. 2013, 16(8):1767-1780

 

13. Zhang XL, Shi J*, Zhao LY, Sun LL, Wang J, Wang GB, Epstein DH, Lu L. Effects of stress on decision-making deficits in formerly heroin-dependent patients after different durations of abstinence. Am J Psychiatry. 2011, 168(6):610-616

 

科研项目