科学研究队伍

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张毓 教授

研究领域: 淋巴细胞发育
电话:
联系邮箱: zhangyu007@bjmu.edu.cn

个人简历

教育部“长江学者”特聘教授、国家杰出青年基金获得者、“973 计划”首席科学家

 

男,1963 年出生,北京大学教授、博士生导师。主要从事淋巴细胞发育研究,包括新的发育调控分子的功能鉴定,胸腺单阳性细胞发育的细胞学过程,T细胞发育后期重要事件的调控,以及胸腺器官的发生与退化。近年来,实验室积极拓展的另一研究方向为肿瘤免疫,包括新的肿瘤相关抗原的鉴定、肿瘤微环境免疫抑制特性的解析及肿瘤疫苗的研发,近五年共以通讯作者发表论文20 余篇。

主要研究领域

1.淋巴细胞发育

2.肿瘤免疫

3.胸腺细胞发生及退化的研究 

代表性论文

1. Jiaqing Hao, Xiao Song, Jingjing Wang, Chengli Guo, Yan Li, Bing Li, Yu Zhang*, Yanhui Yin*. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget. 2015 Oct 19. doi: 10.18632/oncotarget.5973 IF 6.359

2. Xiaofeng Li, Jirun Peng, Yanli Pang, Sen Yu, Xin Yu, Pengcheng Chen, Wenzhen Wang, Wenling Han,  Jun Zhang , Yanhui  Yin*, Yu Zhang*. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015 Oct 6;5:14757. doi: 10.1038/srep14757. IF 5.578

3. Jin R, Gao Y, Zhang S, Teng F, Xu X, Aili A, Wang Y, Sun X, Pang X, Ge Q*, Zhang Y*. Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities. Immunol Cell Biol. 2015 Sep;93(8):744-52. (IF 4.209)

4. Xu, X, Zhang, S, Jin, R., Wang, K., Li, P., Lin, L., Dong, J., Hao, J., Zhang, Y., Sun, X., Pang, X., Qian, X., Zhang, J., Wu, H., Zhang, Y, Ge, Q. Retention and tolerance of autoreactive CD4+ recent thymic emigrants in the liver. J. Autoimmun. 2015, 56:87-97 IF: 8.41)

5. Liu C, Wang HC, Yu S, Jin J, Tang H, Liu YF, Ge Q, Sun XH, Zhang Y*. 2014. Id1 expression promotes T regulatory cell differentiation by facilitating TCR co-stimulation. J Immunol. 193:663-72. (IF 5.536

6. Li Q, Han D, Wang W, Liu X, Sun X, Zhang J, Li R, Zhang Y*. 2014. Toll-like receptor 4-mediated signal regulates IL-7-driven proliferation and differentiation of B cell precursors. Cell Mol Immunol. 11:132-140. (IF 4.185

7. Yang Y, Zhao W, Xu QW, Wang XS, Zhang Y*, Zhang J*.IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells. PLoS One. 2014, 9(5):e97578. (IF 3.534

8. Gao YN, Pei XY, Jin R, Yin C, Shen H, Sun XY, Ge Q, Zhang Y*. Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses. Biochem Biophys Res Commun. 2014 Oct 28;454(2):275-281. (IF 2.281)

科研项目