1. Chemical reprogramming of human somatic cells to pluripotent stem cells. Jingyang Guan, Guan Wang, Jinlin Wang^*, Zhengyuan Zhang, Yao Fu, Lin Cheng, Gaofan Meng, Yulin Lyu, Jialiang Zhu, Yanqin Li, Yanglu Wang, Shijia Liuyang, Bei Liu, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen, Xu Zhang, Shicheng Sun, Weifeng Lai, Yan Shi, Lulu Liu, Lipeng Wang, Cheng Li, Shichun Lu^*, Hongkui Deng^*. Nature, 2022, 605: 325-331.

2. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Yuanyuan Du, Zhen Liang, Shusen Wang, Dong Sun, Xiaofeng Wang, Soon Yi Liew, Shuaiyao Lu, Shuangshuang Wu, Yong Jiang, Yaqi Wang, Boya Zhang, Wenhai Yu, Zhi Lu, Yue Pu, Yun Zhang, Haiting Long, Shanshan Xiao, Rui Liang, Zhengyuan Zhang, Jingyang Guan, Jinlin Wang, Huixia Ren, Yanling Wei, Jiaxu Zhao, Shicheng Sun, Tengli Liu, Gaofan Meng, Le Wang, Jiabin Gu, Tao Wang, Yinan Liu, Cheng Li, Chao Tang, Zhongyang Shen, Xiaozhong Peng, Hongkui Deng^*. Nature Medicine, 2022, 28: 272-282.

3. Automated solution-phase multiplicative synthesis of complex glycans up to a 1,080-mer. Wenlong Yao, De-Cai Xiong, Yun Yang, Chunmei Geng, Zisen Cong, Feifei Li, Bo-Han Li, Xianjin Qin, Li-Na Wang, Wan-Ying Xue, Nengfu Yu, Hanyu Zhang, Xia Wu, Miao Liu & Xin-Shan Ye^*. Nature Synthesis, 2022, 1: 854-863.

4. A pyroptosis nanotuner for cancer therapy. Binlong Chen, Yue Yan, Ye Yang, Guang Cao, Xiao Wang, Yaoqi Wang, Fangjie Wan, Qingqing Yin, Zenghui Wang, Yunfei Li, Letong Wang, Bo Xu, Fuping You^*, Qiang Zhang^*, Yiguang Wang^*. Nature Nanotechnology, 2022, 17: 788-798.

5. The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis. Yenan Fu#, Xi Zhang#, Xiao Liu#, Peng Wang, Wenhui Chu, Wei Zhao, Yunling Wang, Guangbiao Zhou, Yu Yu^*, Hongquan Zhang^*. Signal Transduction and Targeted Therapy, 2022, 7(1): 81.

6. Restoration of dystrophin expression in vivo by suppressing a nonsense mutation through the incorporation of unnatural amino acids. Shi N, Yang Q, Zhang H, Lu J, Abulimiti A, Cheng J, Lin H, Yang X, Wang Y, Tong L, Wang T, Zhang X, Chen H, Xia Q.^*. Nature Biomedical Engineering, 2022, 6(2): 195-206.

7. A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Jianyong Du, Lixia Zheng, Peng Gao, Hang Yang, Wan-Jie Yang, Fusheng Guo, Ruqi Liang, Mengying Feng, Zihao Wang, Zongwang Zhang, Linlu Bai, Ye Bu, Shijia Xing, Wen Zheng, Xuelian Wang, Li Quan, Xinli Hu, Haosen Wu, Zhixing Chen, Liangyi Chen, Ke Wei, Zhe Zhang, Xiaojun Zhu, Xiaolin Zhang, Qiang Tu, Shi-Min Zhao⁎, Xiaoguang Lei^*, Jing-Wei Xiong^*. Cell Stem Cell, 2022, 29, 545.

8. A standardized assay for the quantitative detection of serum HBV RNA in chronic hepatitis B patients. Guangxin Yu, Ran Chen, Sujun Zheng, Yanna Liu, Jun Zou, Zhiqiang Gu, Bei Jiang, Qi Gao, Lizhong Dai^*, Jie Peng^*, Jie Wang^*, Fengmin Lu^*. Emerging Microbes Infectins, 2022, 11(1): 775-785.

9. Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway. Jiaqi Jin, Lei Zhang, Xueying Li, Weizhi Xu, Siyuan Yang, Jiagui Song, Wenhao Zhang, Jun Zhan, Jianyuan Luo, Hongquan Zhang^*. Nucleic Acids Research, 2022, 50(7): 3817–3834.

10. Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging. Yue Yan1, Binlong Chen1, Qingqing Yin, Zenghui Wang, Ye Yang, Fangjie Wan, Yaoqi Wang, Mingmei Tang, Heming Xia, Meifang Chen, Jianxiong Liu, Siling Wang, Qiang Zhang, Yiguang Wang^*. Nature Communications, 2022, 13(1): 2004.

11. Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction. Xiaohai Zhou, Chenyang Zhang, Xueying Wu, Xinli Hu, Yan Zhang, Xuelian Wan, Lixia Zheng, Peng Gao, Jianyong Du, Wen Zheng, Haibao Shang, Keping Hu, Zhengfan Jiang, Yu Nie, Shengshou Hu, Rui-Ping Xiao, Xiaojun Zhu^*, Jing-Wei Xiong^*. Nature Communications, 2022, 13, 6672.

12. Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation. Yunfei Bai, Zhenghao Yang, Xiaochan Xu, Wanqiu Ding, Juntian Qi, Feng Liu, Xiaoxiao Wang, Bin Zhou, Wenpeng Zhang, Xiaomei Zhuang, Guanglu Li, Yang Zhao^*. Hepatology, 2022, 10.1002/HEP.32686.

13. An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer. Yanan Sun, Bochen Lyu, Chang Yang, Bing He, Hua Zhang, Xueqing Wang^*, Qiang Zhang^*, Wenbing Dai^*. Bioactive Materials, 2022, 22, 47-59.

14. Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products. Xikang Zheng, Yan Li, Mengtie Guan, Lingyue Wang, Shilong Wei, Yi-Cheng Li, Chin-Yuan Chang, Zhengren Xu^*. Angewandte Chemie International Edition, 2022, 61, e202208802.

15. Bioinspired Total Synthesis of (+)-Euphorikanin A. Zhuang Chen, Kuan Zhao, and Yanxing Jia^*. Angewandte Chemie International Edition, 2022, 61, e202200576.

16. Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin. Yunpeng Ji, Benke Hong, Ivan Franzoni, Mengyang Wang, Weiqiang Guan, Hongli Jia, Houhua Li^*. Angewandte Chemie International Edition, 2022, 61, e202116136.

17. Creation of a Yeast Strain with Co-Translationally Acylated Nucleosomes. Dan Wu, Yunfeng Zhang, Zhiheng Tang, Xiaoxu Chen, Xinyu Ling, Longtu Li, Wenbing Cao, Wei Zheng, Jiale Wu, Hongting Tang, Xiaoyun Liu^*, Xiaozhou Luo^*, Tao Liu^*.Angewandte Chemie International Edition, 2022, 61(30): e202205570.

18. Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes. Baiying Xing#, Houchao Xu#, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat^*, Donghui Yang^*, and Ming Ma^*. Angewandte Chemie International Edition, 2022, 61, e202209785.

19. Engineering of a Triterpene 3-/6-/2-O-Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity. Meng Zhang, Yang Yi, Bai-Han Gao, Hui-Fei Su, Yang-Oujie Bao, Xiao-Meng Shi, Hai-Dong Wang, Fu-Dong Li, Min Ye^*, and Xue Qiao^*. Angewandte Chemie International Edition, 2022, 61(8), e202113587.

20. Monitoring Dynamic Regulation of Mitochondrial GTP to GDP Ratio with A Genetically Encoded Fluorescent Biosensor. Meiqi Zhang, Bo Yang, Jiayuan Zhang, Yuxin Song, Weibo Wang, Na Li, Yuan Wang, Wenzhe Li, Jing Wang^*. Angewandte Chemie International Edition, 2022, 61, e202201266.

21. Amino-functional metal–organic framework as a general applicable adsorbent for simultaneous enrichment of nine neonicotinoids. Wen Ma^*, Bingxin Yang, Jun Li, Xianjiang Li^*. Chemical Engineering Journal, 2022, 434: 134629.

22. Total Synthesis of (–)-Principinol C. Tianhao Ma†, Hao Cheng†, Mallesham Pitchakuntla, Weihao Ma, and Yanxing Jia^*. Journal of the American Chemical Society, 2022, 144: 20196-20200.

23. Catalytic Electrophilic Halogenation of Arenes with Electron-Withdrawing Substituents. Weijin Wang, Xiaoxue Yang, Rongheng Dai, Zixi Yan, Jialiang Wei, Xiaodong Dou, Xu Qiu, Hongliang Zhang, Chen Wang, Yameng Liu, Song Song^* and Ning Jiao^*. Journal of the American Chemical Society, 2022, 144: 13415-13425.

24. Genetic-code-expanded cell-based therapy for treating diabetes in mice. Chao Chen, Guiling Yu, Yujia Huang, Wenhui Cheng, Yuxuan Li, Yi Sun, Haifeng Ye^*, Tao Liu^*. Nature Chemical Biology, 2022, 18(1): 47-55.

25. Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Xiao-Wen Zhang1, Na Feng1, Yan-Chen Liu, Qiang Guo, Jing-Kang Wang, Yi-Zhen Bai, Xiao-Ming Ye, Zhuo Yang, Heng Yang, Yang Liu, Mi-Mi Yang, Yan-Hang Wang, Xiao-Meng Shi, Dan Liu, Peng-Fei Tu^*, Ke-Wu Zeng^*. Science Advances, 2022, 8, eabo0789.

26. JADE2 is essential for hippocampal synaptic plasticity and cognitive. Minghua Fan, Yongqing Liu, Yongfeng Shang, Yanxue Xue, Jing Liang, Zhuo Huang^*. Biological Psychiatry, 2022, 92(10): 800-814.

27. Non-viral vectors for RNA delivery. Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang, and Jian-Cheng Wang^*. Journal of Controlled Release, 2022, 342: 241-279.

28. A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Chunjie Bao, Jialun Duan, Ying Xie, Yixuan Liu, Peishan Li, Jianwei Li, Huihui Zhao, Haitao Guo, Yanchen Men, Yuxin Ren, Jiarui Xu, Guiling Wang, Wanliang Lu^*. Molecular Therapy: Nucleic Acids, 2022, 29: 836-851.

29. PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity. Sijin Liu, Xi Zhao, Sufang Shui, Biao Wang, Yingxian Cui, Suwei Dong, Tairan Yuwen, and Guoquan Liu^*. Journal of Medicinal Chemistry, 2022, 65: 12176−12187.

30. Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders. Haiwei Li, Shouxin Wang, Wenxiao Ma, Boyang Cheng, Yanliang Yi, Xinyuan Ma, Sulong Xiao^*, Lihe Zhang, and Demin Zhou^*. Journal of Medicinal Chemistry, 2022, 65: 7154-7169.