1. Catalytic remodeling of complex alkenes to oxonitriles through C=C double bond deconstruction. Zengrui Cheng, Kaimeng Huang, Chen Wang, Lili Chen, Xinyao Li, Zhibin Hu, Xinyuan Shan, Peng-Fei Cao, Haofeng Sun, Wei Chen, Chenhao Li, Ziyao Zhang, Hui Tan, Xue Jiang, Guikai Zhang, Zhongying Zhang, Min Lin, Liang Wang, Anmin Zheng, Changjiu Xia*, Teng Wang, Song Song, Xingtian Shu, Ning Jiao*. Science. 2025;387:1083–1090."

2. Late-stage conversion of carboxylic acids to nitriles with Mg and Pd cocatalysis. Junhong Meng, Mithun C. Madhusudhanan, Teng Wang, Zengrui Cheng, Binzhi Zhao, Hongwei Shi, Licheng Yang, Peng Liu*, Ning Jiao*. Nat Catal. 2025;8:1295–1305.

3. Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions. Tan Liu#, Guiyang Wang#, Jiahui Yu#, Mengyuan Li#, Tianbo Peng, Jie Wang, Houhua Li, Xiao-dong Su, Changtao Jiang, Min Ye, Donghui Yang, Ming Ma*. Nat Chem. 2025;17:1107–1118.

4. NAD+ biosynthesis and mitochondrial repair in acute kidney injury via ultrasound-responsive thylakoid-integrating liposomes. Lei Y, Wu Y, Zhuang WR, Zhao H, Nie W, Wu G, Pang DW*, Xie HY*. Nat Biomed Eng. 2025;9(10):1740–1757.

5. A Rapid Chemical Reprogramming System to Generate Human Pluripotent Stem Cells. Yanglu Wang#, Fangqi Peng#, Zhihan Yang#, Lin Cheng#, Jingxiao Cao#, Xiaodi Fu, Huanjing He, Ruyi Cai, Weizhen Zeng, Yingshuai Dong, Guanxian Chen, Gongxin Peng, Shijia Liuyang, Guan Wang, Jinlin Wang, Rong Mu, Cheng Li, Jingyang Guan*, Hongkui Deng*. Nat Chem Bio. 2025;21(7):1030–1038.

6. Chemical reprogramming of human blood cells to pluripotent stem cells. Fangqi Peng#, Yanglu Wang#,*, Lin Cheng#, Ruyi Cai#, Xiaodi Fu#, Zhihan Yang#, Ruoqi Cheng#, Weizhen Zeng, Yingshuai Dong, Jingxiao Cao, Jingping Mao, Jingran Zeng, Tianxing Liu, Guanxian Chen, Qi Lei, Lipeng Wang, Lulu Liu, Shicheng Sun, Cheng Li, Rong Mu, Jingyang Guan*, Hongkui Deng*. Cell Stem Cell. 2025;32(8):1192–1199.e11.

7. Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo. Gaofan Meng, Jiabin Gu, Soon Yi Liew, Jingxiao Cao, Zhihui Wang, Chunyu Ma, Zhenzhen Fu, Hongwen Zhou, Jinlin Wang, Shusen Wang, Sijia Jing, Yiqi Wu, Zhengjun Lei, Shuli Zhi, Yuanyuan He, Cheng Li, Hongkui Deng*. Cell Stem Cell. 2025;32(9):1438–1456.E7

8. Comprehensive mutant chemotyping reveals embedding of a lineage-specific biosynthetic gene cluster in wider plant metabolism. Xue Qiao*, Alan Houghton, James Reed, Burkhard Steuernagel, Jiahe Zhang, Charlotte Owen, Aymeric Leveau, Anastasia Orme, Thomas Louveau, Rachel Melton, Brande B H Wulff, Anne Osbourn*. Proc Natl Acad Sci USA. 2025;122(12):e2417588122.

9. From Alkylarenes to α-Amino Acid Derivatives via C-Difunctionalization. Xi Wang, Jianzhong Liu, Zengrui Cheng, Teng Wang, Jing Peng, Junhong Meng, Yilei Huang, Qi Sun*, Ning Jiao*. J Am Chem Soc. 2025;147:40078–40086.

10. Total Synthesis of Acoapetaludine A Enabled by a Rhodium-Catalyzed Domino Cyclization. Yu Zhang, Liyao Wang, Xiaoguang Lei, Yanxing Jia*. J Am Chem Soc. 2025;147:47904–47910.

11. Total Synthesis of (+)-Mannolide B. Peng Chen, Lijun Chen, Hongpeng Lin, Yanxing Jia*. J Am Chem Soc. 2025;147:636–643.

12. Traceless 6-O-Lysyl Modification of N-Acetylglucosamine Enables Synthesis and Derivatization of Aggregation-Prone GlcNAcylated Peptides. Chen J; Zhang, Q; Mo R; Deng Q; Hu B; Dong S*. J Am Chem Soc. 2025; 147: 41413–41424.

13. Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key Residues Critical for Mono-, Bi-, and Tricyclic Sesquiterpenes Formation. Wu, M.; Torrence, I.; Liu, Y.; Wu, J.; Ge, R.; Ma, K.; Liu, D.; Ren, J.; Fan, S.; Ma, M.; Siegel, J. B.; Tantillo, D. J.; Lin, W.*; Fan, A.* J Am Chem Soc. 2025; 147(12): 10413–10422.

14. Molecular and structural characterization of a chalcone di-C-methyltransferase RdCMT from Rhododendron dauricum and its application in de novo biosynthesis of farrerol in Pichia pastoris. Zhang M#, Bao YO#, Dai Z#, Qian Z, Yu H, Zhou JJ, Chen Y, Wang Z, Wang K, Cai M*, Ye M*. J Am Chem Soc. 2025;147,17132–17143.

15. Insights into the mechanisms of sugar acceptor selectivity of plant flavonoid apiosyltransferases. Wang HT#, Wang ZL#, Chen NH#, Huang W, Zou JL, Tian YG, Ye G, Huang J, Wu R*, Ye M*. J Am Chem Soc. 2025;147,20631–20643.

16. Elucidating the biosynthetic pathway and mechanisms of retrochalcones. Ye L#, Wang ZL#, Xu ZQ, Tian YG, Zhang M, Abe I, Ye M*. J Am Chem Soc. 2025;147,29205–29214.

17. mRNA-Based FRET-FLIM Imaging Platform for Quantifying Lipid 2 Nanoparticle Endosomal Escape and Membrane Damage. Yian Fang; Bin Ma; Zhiqiang Zhao; Ziyan Xuan; Yu Wang; Chuping Huang; Mi Zhang; Lei Zhou; Feng Yao; Kailong Li; Wei You; Xinglin Yang; Jiajia Guo; Yifan Ge; Chenzhong Liao; Yiguang Wang; Lei Miao*. J Am Chem Soc. 2025;147(34):30907–30923.

18. FAP-Synergistic Organ-Targeted mRNA-LNP for Overcoming Delivery Barriers in Hepatic and Pulmonary Fibrosis. Chenlong Wei; Xinzhu Shan; Yuxuan Huang; Bin Ma; Zhiqiang Zhao; Yian Fang; Chengrui Bai; Zihan Zhang; Peng Zhao; Huijuan Zhang; Yu Hou; Tianjiao Ji; Zhongtang Li; Song Song; Fei Xie*; Lei Miao*. J Am Chem Soc. 2026;148(9):9309–9327.

19. Single-Vesicle Electrochemistry in Fresh Brain Slices Enables In Situ Quantification of Vesicular Monoamine. Liu YY, Cao LJ, Zhou JL, Li CQ, Du JC, Xue YF, Li XC*, Mao LQ. J Am Chem Soc. 2025;147(1):149–160.

20. Evolution of Cross-Liking Aptamers for Long-Lasting Membrane Protein Labeling. Siqi Bian, Qianwei Qiu, Chenshuo Zhang, Haiyan Cao, Hong Xuan, Xueling Yan, Jun Li, Wenlong Chen, Xiyang Liu, Yifan Chen, Jinchen Long, Huang Su, Jing Wang*, Liqin Zhang*. J Am Chem Soc. 2025;147(51):46780–46786.

21. Glucuronidase-Instructed Glycopeptide Self-Assembly for Selective Killing of Cancer Cells through Lysosomal Membrane Permeabilization. Xu Z; He C; Li X; Huang L; Cheng B; Dong S*. Angew Chem Int Ed. 2025;64:e202420596.

22. Stereoselective Synthesis of 2-Deoxy--O-Aryl Glycosides by a One-Pot Strategy Involving C-O Coupling and Catecholborane Reduction. Yang-He Wang, You-Hong Niu, Qin Li*, Xin-Shan Ye*. Angew Chem Int Ed. 2025;65:e20547.

23. Decarboxylative Arene Ring-Opening of Benzoic Acids. Ming-Hui Zhu, Zengrui Cheng, Yilei Huang, Zhibin Hu, and Ning Jiao*. Angew. Chem. Int. Ed. 2026, 65, e20084 (1 of 9)

24. Direct regioselective C-3 halogenation of pyridines. Chao Li, Xinyao Li, Jiaxing Li, Zhixing Wang, Dunhuang Ouyang, Ning Jiao*, Song Song*. Nat Synth. 2026;5:36–45.

25. Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis. Cheng R, Li S, Ma X, Zhuang W, Lei Y, He J, Liang C, Nie W*, Xie HY*. Sci Adv. 2025;11(8):eadr1299.

26. Systematic evolution of functional oligonucleotides for targeted protein degradation. Huang Su#, Yifan Chen#, Xuyang Zhao#, Zengyi Lu, Tongxuan Wei, Qinguo Liu, Xiyang Liu, Qinhao Zhang, Siqi Bian, Da Xu, Liqin Zhang*. Chem. 2025;11(5):102408.

27. An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity. Wei Q; Liu D; Xia W; Wang F; Huang L; Zhang J; Wang X; Xu Z; He C; Li W; Shi X; Wang C; Liu Y*; Liu C*; Dong S*. Nat Commun. 2025;16:5815.

28. Comprehensive synthesis and anticoagulant evaluation of a diverse fucoidan library. Si-Cong Chen, Xianjin Qin, Nanyu Xiong, Lisha Lin, Yanfen Wu, Qin Li, Dongyue Sun, De-Cai Xiong, Cassandra E. Callmann, Mingyi Wu*, Xin-Shan Ye*. Nat Commun. 2025;16:4364.

29. A High-Performance Fluorescent Sensor Spatiotemporally Reveals Cell-Type Specific Regulation of Intracellular Adenosine in vivo. Wei, Q.; Bai, Z.; Wang, L.; Wang, J.; Wang, Y.; Hu, Y.; Ding, S.; Ma, Z.; Li, C.; Li, Y.; Zhuo, Y.; Li, W.; Deng, F.; Liu, B.; Zhou, P.; Li, Y.*; Wu, Z.*; Wang, J.* Nat Commun. 2025; 16(1): 4245.

30. Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons. Dong, L., Wang J, Xia Q*. Nat Commun. 2025; 16(1):7825.

31. Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants. Zou JL#, Li HY#, Nie B#, Wang ZL, Zhao CX, Tian YG, Lin LQ, Xu WZ, Hou ZW, Sun WK, Han XX, Zhang M, Wang HT, Li QY, Wang L*, Ye M*. Nat Commun. 2025;16,3109.

32. Elucidation of the biosynthetic pathway of hydroxysafflor yellow A. Wang ZL#, Wang HT#, Chang GW, Ye G, Zhang M, Chen J, Ye M*. Nat Commun. 2025;16,4489.

33. A protease-cleavable liposome for co-delivery of anti-PD-L1 and doxorubicin for colon cancer therapy in mice. Liu Y, Xie Y, Chen Y, Duan J, Bao C, Wang J, Feng H, Wang M, Ren Y, Li P, Luo Q, Xu J, Jiang M, Men Y, Wu Y, Li J, Wang G, Lu W*. Nat Commun. 2025;16(1):2854.

34. Cascade-heterogated proton nanotransistors for multiplex pH-interval imaging. Ye Yang, Binlong Chen, Fangjie Wan, Chuanxun Fu, Meifang Chen, Bin Ma, Ruiyang Zhao, Meijie Pan, Qiang Zhang, Yiguang Wang*. Nat Commun. 2025;16:5770.

35. Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury. Zhiqiang Zhao; Xinzhu Shan; Jing Ding*; Bin Ma; Buyao Li; Wendi Huang; Qingqing Yang; Yian Fang; Junhe Chen; Chenglin Song; Chenlong Wei; Shuai Liu; Xingdi Chen; Shengran Zhang; Yunxuan Liu; Hongkun Wu; Cong Luo; Shaokun Shu; Xue Qiao; Zefeng Wang*; Xueguang Lu*; Lei Miao*. Nat Commun. 2025;16(1):6477.

36. Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway. Shang Yu#, Jin-hui Ding#, Jia-le Wang#, Weize Wang, Peng Zuo, Ao Yang, Zonglin Dai, Yuxin Yin, Jin-peng Sun*, Ling Liang*. Nat Commun. 2025;16:6792.

37. Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A-YTHDF2-dependent mechanism. Liu TT#, Chen LT#, Pei XY#, Hu SN#, Zhuo FF, Chen ZK, Liu Y, Wang JK, Zhang JC, Cao Q, Li L, Wang J, Wei TT, Han B, Tu PF*, Zhao XY*, Xue R*, Zeng KW*. iMeta. 2025;4(6):e70089.

38. Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline. Yong Ding#, Xi Luo#, Jiasheng Guo#, Baiying Xing#, Haoyu Lin#, Haohan Ma, Yicun Wang, Meng Li, Chuan Ye, Sen Yan, Kangjie Lin, Jinxin Zhang, Yingying Zhuo, Qixing Nie, Donghui Yang, Zhipeng Zhang, Yanli Pang, Kai Wang*, Ming Ma*, Luhua Lai*, Changtao Jiang*. Cell. 2025;188:6012–6027.

39. Bidentate N-Ligand-Assisted Gold Redox Catalysis with Hydrogen Peroxide. Shi, H.; Rudolph, M.; Li, J.; Tian, Y.; Dietl, M. C.; Alshurafa, H.; Liu, Y.; Wang, T.; Habeck, H.; Stein, P. M.; Krämer, P.; Rominger, F.; Oeser, T.; Jiao, N.*; Hashmi, A. S. K.* Nat Chem. 2025; 17(6): 822–834.

40. A Continuous Totipotent-like Cell-Based Embryo Model Recapitulates Mouse Embryogenesis from Zygotic Genome Activation to Gastrulation. Ren, Y.; Wang, X.; Liu, H.; Xu, Y.; Cheng, R.; Ren, S.; Li, Z.; Huo, Y.; Li, B.; Guan, J.; Li, C.*; Deng, H.*; Xu, J.* Nat Cell Biol. 2025; 27(11): 1993–2006.

41. Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications. Xia W; Xu Z; Dong H; Zhang S; He C; Li D; Sun B; Bai B; Dong S* Liu C*. J Am Chem Soc. 2025;147:20132–20143.

42. Biosynthesis of plant vitexin-derived flavonoid glycosides in yeast. Zhilan Qian, Haishuang Yu, Chenglin Song, Yang Zhang, Qi Liu, Xudong Qu, Min Ye*, Xue Qiao*, Menghao Cai*. Nat Synth. 2026;5:335–348.