特聘研究员 课题组长 博士生导师
电话：+86-010-82805631
E-mail: hongsen414@pku.edu.cn
个人简历
2021.03至今 北京大学药学院/天然药物与仿生药物国家重点实验室 特聘研究员、课题组长、博导
2016.12-2021.03 博士后研究员 美国斯克里普斯研究所分子医学系（导师：Peng Wu教授）
2014.07-2016.12 博士后 北京大学化学与分子工程学院（导师：陈兴教授）
2009.09-2014.07 理学博士 北京大学生命科学学院/化学与分子工程学院（导师：陈兴教授/谢灿研究员）
研究方向
● 化学糖生物学（重点研究聚糖调控的免疫反应）
● 活细胞糖化学驱动的生物医用新技术
● 合成糖化学
● 聚糖序列特异性检测新方法
代表论著
1．Hong S#,*, Yu C#, Wang P#, Shi Y, Cheng B, Chen M, Chapla D G, Reigh N, Narimatsu Y, Chen X, Clausen H, Moremen K W, Macauley M S, Paulson J C*, Wu P*, Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-cell Lymphoma Therapy. Angew. Chem. Int. Ed. 2020, 60(7): 3603-3610.
2．Hong S#, Feng L#, Yang Y, Jiang H, Hou X, Guo P, Marlow F L, Stanley P, Wu P, In situ Fucosylation for Modulating Live-cell Wnt Signaling. Cell Chem. Biol. 2020, 27(9): 1140-1150.
3．Hong S#, Chen T#, Liu L, Cao C, Rabinowitz J D, Huang Y, Chen X, Live-cell Imaging of NADPH Production from Specific pathways. CCS Chem. 2020, 2: 1642-1648.
4．Hong S, Geramie G, Yu C, Chapla D G, Reigh N, Moremen K W, Xie J, Wu P, hFUT1-based Live Cell Assay to Profile α1-2-fucosides-enhanced Influenza A Virus Infection. ACS Chem. Biol. 2020, 5(4): 819-823.
5．Hong S#, Sahai-Hernandez P#, Chapla D G, Moremen K W, Traver D, Wu P, Direct Visualization of Live Zebrafish Glycan via Single-step Metabolic Labeling with Fluorophore-tagged Nucleotide Sugars. Angew. Chem. Int. Ed. 2019, 58(40): 14327-14333.
Highlight in Nature: Work/Technology & Tools, 2020
6．Hong S, Shi Y, Wu, N C, Grand G, Douthit L, Wang H, Wen Z, Sharpless K B, Wilson I A, Xie J, Wu P, Bacterial Glycosyltransferase-mediated Cell-surface Chemoenzymatic Glycan Modification. Nat. Commun. 2019, 10(1): 1799.
Editors’ Highlights in Organic Chemistry and Chemical Biology, 2019
7．Hong S, Lin L, Xiao M, Chen X, Live-cell Bioorthogonal Raman Imaging. Curr. Opin. Chem. Biol. 2015, 24: 91-96.
8．Hong S#, Chen T#, Zhu Y, Li A, Huang Y, Chen X, Live-cell Stimulated Raman Scattering Imaging of Alkyne-tagged Biomolecules. Angew. Chem. Int. Ed. 2014, 53(23): 5827-5831.
9．Feng L#, Hong S#, Rong J#, You Q, Dai P, Huang R, Tan Y, Hong W, Xie C, Zhao J, Chen X, Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-surface Sialylated Glycans. J. Am. Chem. Soc. 2013, 135(25): 9244-9247.
10．Lin L#, Tian X#, Hong S#, Dai P, You Q, Wang R, Feng L, Xie C, Tian ZQ, Chen X, A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells. Angew. Chem. Int. Ed. 2013, 52(28): 7266-7271.
11．Xie R#, Hong S#, Feng L, Rong J, Chen X, Cell-selective Metabolic Glycan Labeling Based on Ligand-targeted Liposomes. J. Am. Chem. Soc. 2012, 134(24): 9914-9917.
本课题组常年招收博士后及研究生，欢迎申请！有意者请将个人简历发至hongsen414@pku.edu.cn