国家优秀青年基金获得者、万人计划青年拔尖人才
北京大学未来技术学院分子医学研究所，北大清华生命科学联合中心、天然药物及仿生药物国家重点实验室研究员、博士生导师。在iPS细胞、小分子诱导重编程及直接谱系重编程等领域取得多项突破。长期致力于细胞重编程技术的分子机制研究及新方法开发，开展以细胞重编程和细胞命运调控为原理的新药研发，为解决心衰、肝衰等组织纤维化相关疾病提供了基于细胞重编程原理的“再生医疗”新方案。以共同通讯或共同第一作者在Science、Cell、Cell Stem Cell等杂志发表论文20余篇，SCI总引用次数达6000余次，曾获评“中国科学年度十大进展”、“中国高校年度十大科技进展”、细胞出版社“中国年度论文”、“中国生命科学领域年度十大进展”等。
代表性论文
1. Wang H#, Yang J#, Cai Y, Zhao Y*. Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit. Protein & Cell. 2024 Mar 26:pwae013. Epub ahead of print.
2. Nian X, Lin P, Bai Y, Yu D, Yang X, Zhou B, Gao J, Zhao Y*. Osr1-mediated mesothelial transition of liver mesenchymal cells exacerbates fibrotic liver damage. Mol Ther. 2024 Feb 26:S1525-0016(24)00093-5. doi: 10.1016/j.ymthe.2024.02.024. Epub ahead of print.
3. Lin P, Bai Y, Nian X, Chi J, Chen T, Zhang J, Zhang W, Zhou B, Liu Y, Zhao Y*. Chemically induced revitalization of damaged hepatocytes for regenerative liver repair. iScience. 2023 Nov 22; 26(12):108532. doi: https://doi.org/10.1016/j.isci.2023.108532.
4. Tao Y, Yang Y, Yang Z, Wang L, Wang SQ, Zhao Y*. Robust small molecule-aided cardiac reprogramming systems selective to cardiac fibroblasts. iScience. 2023 Nov 14;26(12):108466. doi: 10.1016/j.isci.2023.108466.
5. Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B*, Zhao Y*. An improved factor combination for in vivo reprogramming of cardiac myofibroblast to cardiomyocyte-like cell with dual recombinase tracing. Circulation. 2023 Nov 21;148(21):1728-1731. doi: 10.1161/CIRCULATIONAHA.122.062810.
6. Yang X#, Chen D#, Sun Q#, Wang Y, Xia Y, Yang J, Lin C, Dang X, Cen Z, Liang D, Wei R, Xu Z, Xi G, Xue G, Ye C, Wang LP, Zou P, Wang SQ, Rivera-Fuentes P, Püntener S, Chen Z, Liu Y*, Zhang J*, Zhao Y*. A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems. Cell Discovery. 2023 Jun 6;9(1):53. doi: 10.1038/s41421-023-00543-1.
7. Li J#, Bai Y#, Liu Y, Song Z, Yang Y, Zhao Y*. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. Cell Reports. 2023 May 24;42(6):112566. doi: 10.1016/j.celrep.2023.112566.
8. Li J, Chi J, Yang Y, Song Z, Yang Y, Zhou X, Liu Y*, Zhao Y*. PHDs-seq: a large-scale phenotypic screening method for drug discovery through parallel multi-readout quantification. Cell Regeneration. 2023 Jun 2;12(1):22. doi: 10.1186/s13619-023-00164-9.
9. Bai Y, Yang Z , Xu X , Ding W , Qi J , Liu F , Wang X , Zhou B , Zhang W , Zhuang X, Li G , Zhao Y*. Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation. Hepatology. 2023 May 1;77(5):1550-1565. doi: 10.1002/hep.32686.
10. Yang Z#, Xu X#, Gu C, Nielsen AV, Chen G, Guo F*, Tang C*, Zhao Y*. Chemical Pretreatment Activated a Plastic State Amenable to Direct Lineage Reprogramming. Front Cell Dev Biol. 2022 Mar 25;10:865038. doi: 10.3389/fcell.2022.865038.
11. Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y*, Zhao Y*. Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367.
12. Yang Z#, Xu X#, Gu C#, Li J, Wu Q, Ye C, Nielsen AV, Mao L, Ye J, Bai K, Guo F*, Tang C*, Zhao Y*.Chemicals orchestrate reprogramming with hierarchical activation of mastertranscription factors primed by endogenous Sox17 activation. Commun Biol. 2020 Oct 30;3(1):629. doi: 10.1038/s42003-020-01346-w.
13. Ye J#, Ge J#, Zhang X, Cheng L, Zhang Z, He S, Wang Y, Lin H, Yang W, Liu J, Zhao Y*, Deng H*. Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds. Cell Res. 2016 Jan;26(1):34-45. doi: 10.1038/cr.2015.142.
14. Zhao Y*#, Zhao T#, Guan J#, Zhang X#, Fu Y#, Ye J#, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H*. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell. 2015 Dec 17;163(7):1678-91. doi: 10.1016/j.cell.2015.11.017.
15. Li X#, Zuo X#, Jing J#, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z*, Zhao Y*, Deng H*. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015 Aug 6;17(2):195-203. doi: 10.1016/j.stem.2015.06.003.
16. Hou P#, Li Y#, Zhang X#, Liu C#, Guan J#, Li H#, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y*, Deng H*. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278.
17. Shu J#, Wu C#, Wu Y#, Li Z#, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C*, Zhao Y*, Deng H*. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell. 2013 May 23;153(5):963-75. doi: 10.1016/j.cell.2013.05.001.
18. Zhao Y#, Yin X#, Qin H#, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H*. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 2008 Nov 6;3(5):475-9. doi: 10.1016/j.stem.2008.10.002.
19. Cai J#, Zhao Y#, Liu Y#, Ye F, Song Z, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H*. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology. 2007 May;45(5):1229-39. doi: 10.1002/hep.21582.