学术报告

                       题目：Screening and Profiling Kinase Inhibitors with a Luminescent ADP Detection Platform

                       主讲人：Kevin Hsiao

　　                             Sr. Research Scientist

　　                             Cellular and Biochemical Technologies Group Promega Corporate

　　                             Kevin有超过15年以上的药筛方面的研究经验。特别是在激酶，GPCR药靶方面有资深经验

                      时间：2011年10月14日(本周五)上午10:00

                      地点：重点实验室二楼报告厅

                      内容：1. Promega KES Drug Screening Technologies: ADP-Glo with KES and PI3 Kinase-Glo

　                              2. Promega GPCR & ADME Tox Research Tools

　　【Abstract】

　　Selectivity of a kinase inhibitor towards the target of interest is critical for its advancement through the various phases of drug development. This makes kinase profiling of the inhibitor a common practice during the drug discovery phase. A robust and universal kinase assay is desired at this phase to assess inhibitor selectivity and potency on multiple kinases from different classes that often use substrates with different chemical structures. Here we describe a kinase assay platform that uses the universal ADP-Glo™ technology to attain the sensitivity and reproducibility required for kinase inhibitor screening and profiling.

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